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Titolo:
CYTOMEGALOVIRUS DNA LEVEL ON BIOPSY SPECIMENS DURING TREATMENT OF CYTOMEGALOVIRUS GASTROINTESTINAL-DISEASE
Autore:
COTTE L; DROUET E; BAILLY F; VITOZZI S; DENOYEL GA; TREPO C;
Indirizzi:
HOP HOTEL DIEU,HEPATOGASTROENTEROL & AIDS UNIT,1 PL HOP F-69288 LYON 02 FRANCE SCH MED,DIV INFECT DIS GRENOBLE FRANCE INST PASTEUR,VIROL UNIT LYON FRANCE
Titolo Testata:
Gastroenterology
fascicolo: 2, volume: 111, anno: 1996,
pagine: 439 - 444
SICI:
0016-5085(1996)111:2<439:CDLOBS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; VIRUS-INFECTED PATIENTS; CENTRAL-NERVOUS-SYSTEM; GANCICLOVIR THERAPY; CEREBROSPINAL-FLUID; CMV INFECTION; AIDS PATIENTS; AMPLIFICATION; QUANTITATION; FOSCARNET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
L. Cotte et al., "CYTOMEGALOVIRUS DNA LEVEL ON BIOPSY SPECIMENS DURING TREATMENT OF CYTOMEGALOVIRUS GASTROINTESTINAL-DISEASE", Gastroenterology, 111(2), 1996, pp. 439-444

Abstract

Background & Aims: There is no clear end point for the response to treatment of gastrointestinal human cytomegalovirus (HCMV) disease. HCMV-DNA quantitation on gastrointestinal biopsy specimens has proven its value for the diagnosis of gastrointestinal HCMV disease in patients with acquired immunodeficiency syndrome (AIDS). The aim was to study HCMV-DNA levels on gastrointestinal biopsy specimens during the treatment of gastrointestinal HCMV disease. Methods: HCMV-DNA quantitation wasperformed using two different polymerase chain reaction assays on 90 biopsy specimens obtained before anti-HCMV therapy, during the induction phase, or during maintenance therapy for gastrointestinal HCMV disease in 21 patients with AIDS. Results: HCMV-DNA was detected on all the biopsy specimens ranging from 9 to greater than or equal to 80,000 Eq/0.1 mu g DNA. Pretherapeutic mean level was 69,000 +/- 27,000 Eq/0.1mu g DNA. Induction therapy was followed by a mean decrease of 1.7 +/- 1.3 log(10) Eq/0.1 mu g DNA. HCMV-DNA levels decreased during induction therapy to <1000 Eq/0.1 mu g DNA in 60% of patients but remained >80,000 Eq/0.1 mu g DNA in 20% of patients. Relapse occurred in all thepatients in a mean time of 100 days. HCMV-DNA level at the end of theinduction phase seems to influence the time to relapse. Conclusions: Quantitation of HCMV-DNA on gastrointestinal biopsy specimens seems tobe useful for monitoring gastrointestinal HCMV disease in patients with AIDS.

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Documento generato il 20/09/20 alle ore 19:27:38