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Titolo:
ANDROGENS, BRAIN, AND BEHAVIOR
Autore:
RUBINOW DR; SCHMIDT PJ;
Indirizzi:
NIMH,BLDG 10,ROOM 3N238,10 CTR DR,MSC 1276 BETHESDA MD 20892
Titolo Testata:
The American journal of psychiatry
fascicolo: 8, volume: 153, anno: 1996,
pagine: 974 - 984
SICI:
0002-953X(1996)153:8<974:ABAB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA TESTOSTERONE LEVELS; SEXUALLY DIMORPHIC NUCLEUS; HYPOGONADAL MALE-PATIENTS; AGGRESSIVE-BEHAVIOR; SERUM TESTOSTERONE; FEMALE RATS; REPLACEMENT THERAPY; STEROID-HORMONES; RHESUS-MONKEYS; DEPRESSED MEN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
179
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Rubinow e P.J. Schmidt, "ANDROGENS, BRAIN, AND BEHAVIOR", The American journal of psychiatry, 153(8), 1996, pp. 974-984

Abstract

Objective: This article defines androgens (and anabolic steroids), describes their mechanisms of action, and summarizes their behavioral effects and relevance in animals and humans. Method: A MEDLINE-derived review of the literature on androgens and behavior was performed; pivotal earlier publications were also obtained and included in the review. Results: In animals, the effects of androgens on brain structure and function are well-established and profound with behavioral implications extending far beyond reproduction. Androgens play a prominent role in the organization or programming of brain circuits, which are subsequently activated by gonadal steroids. In humans, roles for androgens have been described albeit inconsistently, in the regulation of sexuality, aggression, cognition, emotion, and personality. The relevance of androgens for psychiatry is further suggested by gender-related differences in pharmacokinetics/pharmacodynamics and in the prevalence, course, and treatment response characteristics of several psychiatric disorders. Direct psychoactive effects of exogenously administered androgens have been described for many years, most recently in reports of the psychotoxic effects of anabolic steroids. Conclusions: Data from both animals and humans suggest that the biological and behavioral responses to androgens are context-dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:28:38