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Titolo:
ANTIPHOSPHOLIPID ANTIBODIES IN WOMEN HAVING IN-VITRO FERTILIZATION
Autore:
BIRDSALL MA; LOCKWOOD GM; LEDGER WL; JOHNSON PM; CHAMLEY LW;
Indirizzi:
UNIV OXFORD,OXFORD RADCLIFFE HOSP,WOMENS CTR,NUFFIELD DEPT OBSTET & GYNAECOL OXFORD OX3 9DU ENGLAND UNIV LIVERPOOL,DEPT IMMUNOL LIVERPOOL L69 3BX MERSEYSIDE ENGLAND UNIV AUCKLAND,NATL WOMENS HOSP,DEPT OBSTET & GYNAECOL AUCKLAND NEW ZEALAND
Titolo Testata:
Human reproduction
fascicolo: 6, volume: 11, anno: 1996,
pagine: 1185 - 1189
SICI:
0268-1161(1996)11:6<1185:AAIWHI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; ANTICARDIOLIPIN ANTIBODIES; INVITRO FERTILIZATION; EMBRYO-TRANSFER; ANTICOAGULANT; CARDIOLIPIN; POPULATION; PREVALENCE; PREGNANCY;
Keywords:
ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID ANTIBODIES; GROWTH RETARDATION; IMPLANTATION; IVF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Birdsall et al., "ANTIPHOSPHOLIPID ANTIBODIES IN WOMEN HAVING IN-VITRO FERTILIZATION", Human reproduction, 11(6), 1996, pp. 1185-1189

Abstract

Antiphospholipid antibodies have an established association with pregnancy complications such as recurrent miscarriage, growth retardation,placental abruption and stillbirth but their mechanism of action is unclear, We have investigated whether antiphospholipid antibodies occurmore frequently in women having in-vitro fertilization (IVF) and whether their presence is associated with the likelihood of failed implantation. We studied 240 women undergoing IVF treatment who were less than or equal to 38 years and had attempted fewer than three previous IVFcycles. Antiphospholipid antibodies (anticardiolipin and antiphosphatidyl serine immunoglobulin G and immunoglobulin M) were present in 36 out of 240 (15%) of the study population and were not associated with a failed IVF cycle or miscarriage. There was no association between the cause of infertility and the presence of antiphospholipid antibodies, Antiphospholipid antibodies were not detected more frequently in women with previous attempts at IVF compared with women having their first cycle, indicating that the high incidence of these antibodies is notdue to the IVF treatment. There was a strong association between the presence of antiphospholipid antibodies and intrauterine growth retardation in singleton pregnancies (P < 0.005). We recommend routine screening for the presence of antiphospholipid antibodies in women having IVF in order to identify those pregnancies at increased risk of intrauterine growth retardation.

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Documento generato il 01/12/20 alle ore 19:43:07