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Titolo:
MONOCYTE CHEMOATTRACTANT PROTEIN-1 GENE-EXPRESSION IN PROSTATIC HYPERPLASIA AND PROSTATE ADENOCARCINOMA
Autore:
MAZZUCCHELLI L; LOETSCHER P; KAPPELER A; UGUCCIONI M; BAGGIOLINI M; LAISSUE JA; MUELLER C;
Indirizzi:
HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT PATHOL,75 FRANCIS ST BOSTON MA 02115 UNIV BERN,INST PATHOL BERN SWITZERLAND UNIV BERN,THEODOR KOCHER INST BERN SWITZERLAND
Titolo Testata:
The American journal of pathology
fascicolo: 2, volume: 149, anno: 1996,
pagine: 501 - 509
SICI:
0002-9440(1996)149:2<501:MCPGIP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR LEUKOCYTES; INFLAMMATORY BOWEL-DISEASE; LOW-DENSITY-LIPOPROTEIN; AMINO-ACID ANALYSIS; CHEMOTACTIC CYTOKINES; ENHANCED PRODUCTION; MALIGNANT-CELLS; MESSENGER-RNA; IN-VIVO; INTERLEUKIN-8;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
L. Mazzucchelli et al., "MONOCYTE CHEMOATTRACTANT PROTEIN-1 GENE-EXPRESSION IN PROSTATIC HYPERPLASIA AND PROSTATE ADENOCARCINOMA", The American journal of pathology, 149(2), 1996, pp. 501-509

Abstract

Human monocyte chemoattractant protein-1 (MCP-1) has been shown to net as a chemokine in the recruitment of monocyte/macrophages during inflammation states. Furthermore, there is increasing evidence that MCP-1is involved in the recruitment of tumor-associated macrophages. In vivo, one of the major cellular sources of MCP-1 are the smooth muscle cells. As MCP-1 gene expression and/or protein production in these cells is not necessarily correlated with the accumulation of inflammatory cells, there might possibly be additional functions of this cytokine. rn the present study, we investigated by use of S-35-labeled antisenseRNA probes whether the MCP-1 gene is expressed in tissue specimens ofbenign prostatic hyperplasia (n = 13) and specimens of prostate carcinoma (n = 8), both of which are characterized by a prominent fibromuscular stroma and inconspicuous inflammatory infiltrates. MCP-1 transcripts were located in stromal smooth muscle cells and, additionally, ittbasal cells of benign prostatic glands. In prostate carcinoma, the number of MCP-1 mRNA-expressing cells was significantly less than in benign prostatic hyperplasia. MCP-1 transcripts were located in preservedfibromuscular stroma and in basal cells of entrapped non-neoplastic glands but not in carcinomatous cells. Immunohistochemical staining with polyclonal antibodies raised against MCP-1 revealed strong reactivity in the fibromuscular stroma surrounding both benign and malignant glands MCP-1 gene expression or immunoreactivity for anti-MCP-1 antibodies was trot related to the rare, lymphocytic interstitial infiltrates. The results show that 1) in the absence of significant leukocyte accumulation, it is unlikely that MCP-1 exerts chemotactic functions in the prostate and 2) that MCP-1, in contrast to previous findings in a wide variety of other human neoplasms, is not expressed in carcinomatouscells of the prostate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:15:42