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Titolo:
INCREASE IN FASTING INSULIN AND GLUCOSE OVER 7 YEARS WITH INCREASING WEIGHT AND INACTIVITY OF YOUNG-ADULTS - THE CARDIA STUDY
Autore:
FOLSOM AR; JACOBS DR; WAGENKNECHT LE; WINKHART SP; YUNIS C; HILNER JE; SAVAGE PJ; SMITH DE; FLACK JM;
Indirizzi:
UNIV MINNESOTA,SCH PUBL HLTH,DIV EPIDEMIOL,SUITE 300,1300 S 2ND ST MINNEAPOLIS MN 55454 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 UNIV MINNESOTA,SCH MED,DEPT MED,DIV GEN & PREVENT MED MINNEAPOLIS MN 55455 UNIV ALABAMA,CARDIA COORDINATING CTR BIRMINGHAM AL 00000 NHLBI,NIH,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV ALABAMA,DIV PREVENT MED BIRMINGHAM AL 00000 BOWMAN GRAY SCH MED,HYPERTENS CTR WINSTON SALEM NC 00000
Titolo Testata:
American journal of epidemiology
fascicolo: 3, volume: 144, anno: 1996,
pagine: 235 - 246
SICI:
0002-9262(1996)144:3<235:IIFIAG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; UNITED-STATES POPULATION; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; RESISTANCE SYNDROME; PHYSICAL-ACTIVITY; FOLLOW-UP; HYPERINSULINEMIA; RISK; NIDDM;
Keywords:
EXERCISE; GLUCOSE; INSULIN; LONGITUDINAL STUDIES; OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Folsom et al., "INCREASE IN FASTING INSULIN AND GLUCOSE OVER 7 YEARS WITH INCREASING WEIGHT AND INACTIVITY OF YOUNG-ADULTS - THE CARDIA STUDY", American journal of epidemiology, 144(3), 1996, pp. 235-246

Abstract

To characterize 7-year changes in fasting serum insulin and glucose concentrations, the authors analyzed population-based data on 3,095 nondiabetic black and white men and women who were initially aged 18-30 years in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Measurements were made of fasting insulin (by an assay with little cross-reactivity to proinsulin) and fasting glucose on frozen samples from baseline and Year 7 examinations. Over the 7-year period, mean fasting insulin increased 10-25%, mean fasting glucose increased 7-10%, and mean body mass increased 7-12% across the four race-, sex-groups. The strongest predictor of both insulin increase and glucose increase was an increase in body mass over the 7 years. Adjusted for age and examination time period in race-, sex-specific repeated measures analyses, fasting insulin increased longitudinally by approximately 5 mu U/mL per 5 kg/m(2) increase in body mass index (p < 0.05). Adjusted for age and time period, fasting insulin increased over the 7 years by approximately 2.5 mu U/mL per 0.08 unit increase in waist/hip ratio (p < 0.05), although this association was much stronger cross-sectionally. In a similar model, each 100 unit decrease in physical activity longitudinally predicted a 0.1-0.2 mu U/mL increase in fasting insulin (p < 0.05 in black men only); this association was stronger and statistically significant in all race-, sex-groups cross-sectionally. Fasting insulin was not associated with energy intake either cross-sectionally or longitudinally, but age- and time-adjusted associations of insulin change with change in several nutrients (e.g., energy from fat) were statistically significant in whites. The authors conclude that marked increase in weight in young adulthood adversely alters glucose and insulin metabolism, and that, if not reversed, this may lead to harmful health consequences in later life.

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Documento generato il 04/12/20 alle ore 15:13:27