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Titolo:
SKP1 CONNECTS CELL-CYCLE REGULATORS TO THE UBIQUITIN PROTEOLYSIS MACHINERY THROUGH A NOVEL MOTIF, THE F-BOX
Autore:
BAI C; SEN P; HOFMANN K; MA L; GOEBL M; HARPER JW; ELLEDGE SJ;
Indirizzi:
BAYLOR COLL MED,HOWARD HUGHES MED INST HOUSTON TX 77030 BAYLOR COLL MED,HOWARD HUGHES MED INST HOUSTON TX 77030 BAYLOR COLL MED,VERNA & MARRS MCLEAN DEPT BIOCHEM HOUSTON TX 77030 BAYLOR COLL MED,DEPT MOL & HUMAN GENET HOUSTON TX 77030 SWISS INST EXPTL CANC RES,BIOINFORMAT GRP CH-1066 LAUSANNE SWITZERLAND INDIANA UNIV,SCH MED,DEPT BIOCHEM & MOL BIOL,WALTHER ONCOL CTR INDIANAPOLIS IN 46202
Titolo Testata:
Cell
fascicolo: 2, volume: 86, anno: 1996,
pagine: 263 - 274
SICI:
0092-8674(1996)86:2<263:SCCRTT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; ANAPHASE TRANSITION; BUDDING YEAST; PROTEIN; KINASE; DESTRUCTION; INHIBITOR; PATHWAY; MITOSIS; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
C. Bai et al., "SKP1 CONNECTS CELL-CYCLE REGULATORS TO THE UBIQUITIN PROTEOLYSIS MACHINERY THROUGH A NOVEL MOTIF, THE F-BOX", Cell, 86(2), 1996, pp. 263-274

Abstract

We have identified the yeast and human homologs of the SKP1 gene as asuppressor of cdc4 mutants and as a cyclin F-binding protein. Skp1p indirectly binds cyclin A/Cdk2 through Skp2p, and directly binds Skp2p,cyclin F, and Cdc4p through a novel structural motif called the F-box. SKP1 is required for ubiquitin-mediated proteolysis of Cln2p, Clb5p,and the Cdk inhibitor Sic1p, and provides a link between these molecules and the proteolysis machinery. A large number of proteins contain the F-box motif and are thereby implicated in the ubiquitin pathway. Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:24:02