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Titolo:
NOVEL ASYMMETRIC PHOTOSENSITIZERS - AN IN-VITRO STUDY
Autore:
HAYLETT AK; FORBES E; MACLENNAN A; TRUSCOTT TG; MOORE JV;
Indirizzi:
PATERSON INST CANC RES,DEPT EXPTL RADIAT ONCOL,LASER ONCOL PROGRAMME MANCHESTER M20 4BX LANCS ENGLAND PAISLEY COLL TECHNOL,DEPT CHEM & CHEM ENGN PAISLEY PA1 2BE RENFREW SCOTLAND UNIV KEELE,DEPT CHEM KEELE ST5 5BG STAFFS ENGLAND
Titolo Testata:
Cancer letters
fascicolo: 2, volume: 105, anno: 1996,
pagine: 187 - 193
SICI:
0304-3835(1996)105:2<187:NAP-AI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTODYNAMIC THERAPY; CELLULAR-UPTAKE; TUMOR-UPTAKE; CELLS; CANCER; MITOCHONDRIAL; RHODAMINE-123; LIPOPROTEINS; PORPHYRINS; AGENTS;
Keywords:
PHOTODYNAMIC THERAPY; MELANOMA; CLONOGENIC ASSAY; NOVEL PHOTOSENSITIZERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Haylett et al., "NOVEL ASYMMETRIC PHOTOSENSITIZERS - AN IN-VITRO STUDY", Cancer letters, 105(2), 1996, pp. 187-193

Abstract

A series of compounds based on an asymmetrical protoporphyrin molecule have been examined, The paired groups of sensitizers differed in terms of the presence or absence of a permanent positive charge, in the alkyl side chain length and in having either a primary or secondary amine substituent. The effects of these variables on drug uptake, partition coefficient and photodynamic eel kill were tested. Drug uptake and partition coefficient were shown to be correlated. Differences in gross uptake were found within paired groups of sensitizers although cell-associated uptake alone did not correlate with clonogenic cell survival, Of the compounds tested it was the sensitizers with alkyl side chains, rather than the permanently positively charged compounds, which resulted in the greatest degree of clonogenic cell kill.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:34:52