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Titolo:
EXPRESSION OF PROGRAMMED CELL-DEATH REGULATORY P53 AND BCL-2 PROTEINSIN ORAL LESIONS
Autore:
RAVI D; NALINAKUMARI KR; RAJARAM RS; NAIR MK; PILLAI MR;
Indirizzi:
REG CANC CTR,DIV LAB MED THIRUVANANTHAPURAM 695011 KERALA INDIA REG CANC CTR,DIV LAB MED THIRUVANANTHAPURAM 695011 KERALA INDIA REG CANC CTR,DIV DENT SURG THIRUVANANTHAPURAM 695011 KERALA INDIA REG CANC CTR,DIV RADIAT ONCOL THIRUVANANTHAPURAM 695011 KERALA INDIA MED COLL HOSP,DIV DENT SURG THANJAVUR INDIA
Titolo Testata:
Cancer letters
fascicolo: 2, volume: 105, anno: 1996,
pagine: 139 - 146
SICI:
0304-3835(1996)105:2<139:EOPCRP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER; OVEREXPRESSION; ONCOPROTEIN; CARCINOMAS; MUTATIONS; APOPTOSIS; INDIA; GENE;
Keywords:
ORAL CANCER; P53; BCL-2; IMMUNOCYTOCHEMICAL EVALUATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
D. Ravi et al., "EXPRESSION OF PROGRAMMED CELL-DEATH REGULATORY P53 AND BCL-2 PROTEINSIN ORAL LESIONS", Cancer letters, 105(2), 1996, pp. 139-146

Abstract

With the ultimate goal of characterizing the molecular pathogenesis of oral cancer, the most predominant malignancy in India, immmunocytochemical evaluation of p53 and bcl-2 proteins was carried out in hypeplastic oral mucosa, dysplastic oral mucosa and invasive oral cancer. Allsubjects gave a similar and almost uniform history of prolonged use of betal quid and tobacco. Expression of p53 was insignificant while bcl-2 was absent in hyperplastic leukoplakia lesions. Both proteins werehowever expressed in leukoplakia with apparent dysplasia. Almost all invasive cancer lesions showed high levels of both p53 and bcl-2. Goodcorrelation was therefore evident between expression of these two proteins and increasing histologic abnormality. Moreover relative risk evaluation revealed that lesions expressing p53 and bcl-2 had a high probability of having a histology of dysplasia or worse. Since it has been previously shown that wild type p53 regulates the expression of bcl-2, it may be presumed that the protein detected in the dysplastic and malignant oral tissue is of the mutant type. It is also known that p53is a positive regulator of programmed cell death or apoptosis while bcl-2 is an anti-apoptotic protein. This suggests the possibility that alterations in p53 followed by over-expression of bcl-2 occur early inoral carcinogenesis resulting in defective apoptosis and subsequent tumor progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:19:34