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Titolo:
THE ROLE OF HIV TYPE-1 PHENOTYPE AND GENOTYPE IN LONG-TERM RESPONDERSTO ZIDOVUDINE THERAPY
Autore:
ANGARANO G; MONNO L; VIVIRITO MC; APPICE A; ROMANELLI C; GIANNELLI A; LAGRASTA L; FRACASSO C; FIORE JR; MILAZZO F;
Indirizzi:
UNIV BARI POLICLIN,CLIN INFECT DIS,PIAZZA G CESARE 11 I-70124 BARI ITALY OSPED L SACCO,DIV INFECT DIS 1 MILAN ITALY
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 11, volume: 12, anno: 1996,
pagine: 969 - 975
SICI:
0889-2229(1996)12:11<969:TROHTP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; SYNCYTIUM-INDUCING PHENOTYPE; AIDS-RELATED COMPLEX; PLACEBO-CONTROLLED TRIAL; HIGH-LEVEL RESISTANCE; REVERSE-TRANSCRIPTASE; BIOLOGICAL PHENOTYPE; DISEASE PROGRESSION; VIRAL PHENOTYPE; DOUBLE-BLIND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
G. Angarano et al., "THE ROLE OF HIV TYPE-1 PHENOTYPE AND GENOTYPE IN LONG-TERM RESPONDERSTO ZIDOVUDINE THERAPY", AIDS research and human retroviruses, 12(11), 1996, pp. 969-975

Abstract

We performed a cross-sectional and partly retrospective virological evaluation of 31 long-term responders (LTRs) to zidovudine (ZDV) (persistent increase in the CD4(+) cell counts without progression of HIV infection throughout a period of ZDV therapy >3 years) and 17 well-matched controls who developed a marked immunological deterioration over a 24-month period of ZDV therapy. The biological phenotype of HIV-1 was assessed by testing the capacity of the isolates to replicate in the MT-2, HUT-78, C-8166, and U-937 T cell lines, and mutations at codons 215 and 41 of RT were checked in proviral DNA from uncultured PBMCs. Slow/low non-syncytium-inducing (S/L-NSI) and rapid/high syncytium-inducing (R/H-SI) variants were detected in 25 (81%) acid 2 (6%) LTRs, respectively, HIV-1 could not be isolated in the remaining four LTRs (13%), Conversely, 12 of 17 (71%) controls yielded R/H-SI variants, Conversion from the S/L-NSI to WH-SI phenotype occurred in 5 controls but in none of tile 18 LTRs tested, Mutant sequences in proviral DNA from control PBMCs were consistently detected (94%), while a wild-type sequence of the residues investigated was found in the majority of LTRs (77%). In our series, patients who received immunological and clinical benefits even after prolonged ZDV treatment had S/L-NSI viruses and a low risk to develop ZDV resistance, Conversely, subjects who demonstrated an immunological and clinical deterioration yielded R/H-SI variants orshifted from S/L-NSI to R/H-SI phenotypes and were at higher risk to develop mutations indicating ZDV resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:28:04