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Titolo:
MOLECULAR-BIOLOGY OF APO-E ALLELES IN ALZHEIMERS AND NON-ALZHEIMERS DEMENTIAS
Autore:
MORRIS CM; MASSEY HM; BENJAMIN R; LEAKE A; BROADBENT C; GRIFFITHS M; LAMB H; BROWN A; INCE PG; TYRER S; THOMPSON P; MCKEITH IG; EDWARDSON JA; PERRY RH; PERRY EK;
Indirizzi:
NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT,WESTGATE RD NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,DEPT NEUROPATHOL NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND
Titolo Testata:
Journal of neural transmission. Supplementum
fascicolo: 47, , anno: 1996,
pagine: 205 - 218
SICI:
0303-6995(1996):47<205:MOAAIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E GENOTYPE; AMYLOID-BETA-PEPTIDE; LEWY BODY DEMENTIA; ISOFORM-SPECIFIC INTERACTIONS; AGE-MATCHED CONTROLS; E EPSILON-2 ALLELE; LATE-ONSET; SENILE DEMENTIA; E POLYMORPHISM; DOWNS-SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Morris et al., "MOLECULAR-BIOLOGY OF APO-E ALLELES IN ALZHEIMERS AND NON-ALZHEIMERS DEMENTIAS", Journal of neural transmission. Supplementum, (47), 1996, pp. 205-218

Abstract

Current research into the aetiology of the dementias is focused upon genetic factors which give rise to the disease process. Recently the Apolipoprotein E gene (APO E) and in particular the epsilon 4 allele has been shown to be a risk factor for late onset Alzheimer's disease (AD) where there is an increased frequency of the epsilon 4 allele. The epsilon 4 allele has also been shown to reduce the age at onset of dementia in AD in a dose dependant manner, with the epsilon 2 allele having an opposing effect. We have genotyped a large series of clinically and neuropathologically confirmed cases of AD and found the expected increase in the Apolipoprotein epsilon 4 allele frequency when comparedto a control population. Similarly, in Lewy Body Dementia (LED) an increased epsilon 4 frequency is also found though a normal epsilon 2 frequency exists, unlike in AD where the epsilon 2 frequency is reduced. No changes in APO E allele frequencies were found in presenile AD, Parkinson's disease with or without dementia, or in Down's syndrome. No association was found between any of the APO E alleles and the histopathological indices of AD, cortical senile plaques and neurofibrillary tangles, in any disease category. Neurochemical indicators of AD, lossof choline acetyltransferase activity was also unaffected by APO E genotype. Whilst their appears to be a strong association between the APO E allele and AD and also in LED, other related neurodegenerative disorders associated with dementia do not show such a linkage. Changes inthe epsilon 2 allele frequency may indicate a genetic difference between AD and LED. The epsilon 4 allele does not appear to influence the burden of AD type pathology and this is particularly relevant given the relative lack of NFT in LED indicating that factors other than SP orNFT may govern the onset of dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:58:49