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Titolo:
STRUCTURE, FUNCTION, AND REGULATION OF THE MAMMALIAN FACILITATIVE GLUCOSE-TRANSPORTER GENE FAMILY
Autore:
OLSON AL; PESSIN JE;
Indirizzi:
UNIV IOWA,DEPT PHYSIOL & BIOPHYS IOWA CITY IA 52242
Titolo Testata:
Annual review of nutrition
, volume: 16, anno: 1996,
pagine: 235 - 256
SICI:
0199-9885(1996)16:<235:SFAROT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; STIMULATED INSULIN-SECRETION; DEPENDENT DIABETES-MELLITUS; EXOFACIAL LIGAND-BINDING; BETA-CELL GLUCOKINASE; BLOOD-BRAIN-BARRIER; RAT ADIPOSE CELL; HUMAN GLUT4 GENE; HIGH-FAT DIET; TRANSGENIC MICE;
Keywords:
INSULIN; GLUT1; GLUT2; GLUT3; GLUT4;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
143
Recensione:
Indirizzi per estratti:
Citazione:
A.L. Olson e J.E. Pessin, "STRUCTURE, FUNCTION, AND REGULATION OF THE MAMMALIAN FACILITATIVE GLUCOSE-TRANSPORTER GENE FAMILY", Annual review of nutrition, 16, 1996, pp. 235-256

Abstract

The facilitative transport of glucose across the plasma membranes of mammalian cells is catalyzed by a family of glucose transport proteins(GLUT). Four glucose transport proteins and a fructose transport protein have been identified. These transport proteins have unique tissue distributions and biochemical properties under- lying specific physiologic functions. GLUT1, the first GLUT isoform identified, is expressedat highest levels in the endothelial of barrier tissues such as bloodvessels and the blood-brain barrier. GLUT2, found predominantly in liver, intestine, kidney, and pancreatic beta-cells, is a low-affinity glucose transport protein that is part of the glucose sensor in pancreatic beta-cells and facilitates either glucose uptake or efflux from the liver depending on the nutritional state. GLUT3 is the glucose transporter responsible for maintaining an adequate glucose supply to neurons. GLUT4 is the insulin-regulated glucose transporter found in adipose tissues, heart muscles, and skeletal muscles that is responsible forinsulin-regulated glucose disposal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:18:48