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Titolo:
WHAT HAVE WE LEARNED FROM FUNCTIONAL IMAGING STUDIES IN SCHIZOPHRENIA- THE ROLE OF FRONTAL, STRIATAL AND TEMPORAL AREAS
Autore:
VELAKOULIS D; PANTELIS C;
Indirizzi:
UNIV MELBOURNE,MENTAL HLTH RES INST,NH & MRC SCHIZOPHRENIA RES UNIT PARKVILLE VIC AUSTRALIA UNIV MELBOURNE,DEPT PSYCHIAT PARKVILLE VIC 3052 AUSTRALIA ROYAL PK HOSP,COGNIT NEUROPSYCHIAT UNIT PARKVILLE VIC AUSTRALIA
Titolo Testata:
Australian and New Zealand Journal of Psychiatry
fascicolo: 2, volume: 30, anno: 1996,
pagine: 195 - 209
SICI:
0004-8674(1996)30:2<195:WHWLFF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; MAGNETIC-RESONANCE SPECTROSCOPY; DORSOLATERAL PREFRONTAL CORTEX; D2-DOPAMINE RECEPTOR OCCUPANCY; NEWLY-DIAGNOSED SCHIZOPHRENIA; DRUG-NAIVE SCHIZOPHRENICS; BRAIN GLUCOSE-METABOLISM; D2 DOPAMINE-RECEPTORS; COMPUTED-TOMOGRAPHY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
112
Recensione:
Indirizzi per estratti:
Citazione:
D. Velakoulis e C. Pantelis, "WHAT HAVE WE LEARNED FROM FUNCTIONAL IMAGING STUDIES IN SCHIZOPHRENIA- THE ROLE OF FRONTAL, STRIATAL AND TEMPORAL AREAS", Australian and New Zealand Journal of Psychiatry, 30(2), 1996, pp. 195-209

Abstract

Objectives: Functional imaging technologies allow assessment of cerebral blood flow, cerebral metabolism, cellular metabolic processes, cerebral receptor density and occupancy. This review examines the contribution of such studies to our understanding of schizophrenia. The role of the frontal lobes, the basal ganglia, the temporal lobes and the neuronal circuits which connect them is examined with respect to this literature. Method: All studies in schizophrenia using positron emissiontomography, single photon emission computerised tomography, xenon studies, functional and spectroscopic magnetic resonance imaging formed the basis of this review. Only those studies published in English were reviewed. Results: The most consistent finding in schizophrenia has been that of hypofrontality, while the results of studies examining subcortical structures provide preliminary support for the concept of fronto-striatal dysfunction. Functional imaging has not yet provided consistent results in the study of temporal lobe function. Although receptor studies have shed light on the actions of antipsychotic medications,the findings for dopamine receptor numbers remain controversial. Spectroscopic and functional MRI remain in their infancy as research toolsin schizophrenia. Conclusions: Although there are significant methodological issues to be addressed, functional imaging technology is providing increasing insights into schizophrenia and its treatment. Future research will be truly multidisciplinary as it will require the collaboration of psychiatrists, imaging physicians, neuropsychologists and neuroscientists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:02:10