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Titolo:
MODIFICATION OF THE EFFECTS OF 7-OH-DPAT, A DOPAMINE D3-RECEPTOR AGONIST, ON MORPHINE-INDUCED HYPERLOCOMOTION BY DIABETES
Autore:
KAMEI J; SAITOH A;
Indirizzi:
HOSHI UNIV,FAC PHARMACEUT SCI,DEPT PATHOPHYSIOL & THERAPEUT,SHINAGAWAKU,4-41 EBARA 2-CHOME TOKYO 142 JAPAN
Titolo Testata:
Life sciences
fascicolo: 9, volume: 59, anno: 1996,
pagine: 773 - 780
SICI:
0024-3205(1996)59:9<773:MOTEO7>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; VENTRAL TEGMENTAL AREA; RECEPTOR; MICE; RAT; ACTIVATION; ENKEPHALIN; INCREASE; NEURONS; RELEASE;
Keywords:
DOPAMINE D3 RECEPTORS; 7-OH-DPAT; SPONTANEOUS LOCOMOTOR ACTIVITY; MORPHINE; DIABETIC MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J. Kamei e A. Saitoh, "MODIFICATION OF THE EFFECTS OF 7-OH-DPAT, A DOPAMINE D3-RECEPTOR AGONIST, ON MORPHINE-INDUCED HYPERLOCOMOTION BY DIABETES", Life sciences, 59(9), 1996, pp. 773-780

Abstract

We examined the effect of 7-OH-DPAT on spontaneous locomotor activitythat is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity indiabetic mice, but not in nondiabetic mice. When mice were pretreatedwith of 7-OK-DPAT (0.1 mg/kg), morphine-induced enhanced locomotor activity in nondiabetic mice, but not in diabetic mice, was significantly reduced. Furthermore, 7-OH-DPAT (0.1 mg/kg) significantly attenuatedthe morphine-induced increase in DA turnover in both nondiabetic and diabetic mice. However, DA turnover was significantly greater in diabetic mice than in nondiabetic mice. Thus, it is likely that the enhanced spontaneous locomotor activity in diabetic mice may be partially related to the down-regulation of D3-receptor-mediated modulation of dopamine release in the limbic area.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:01:10