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Titolo:
ASSOCIATION OF BCL-2, BAX, BCL-XL AND INTEULEUKIN-1-BETA-CONVERTING ENZYME EXPRESSION WITH INITIAL RESPONSE TO CHEMOTHERAPY IN ACUTE MYELOID-LEUKEMIA
Autore:
STOETZER OJ; NUSSLER V; DARSOW M; GULLIS E; PELKAFLEISCHER R; SCHEEL U; WILMANNS W;
Indirizzi:
GSF MUNICH,INST CLIN HEMATOL,MARCHIONISTR 25 D-81377 MUNICH GERMANY UNIV MUNICH,DEPT HEMATOL & ONCOL MUNICH GERMANY
Titolo Testata:
Leukemia
, volume: 10, anno: 1996, supplemento:, 3
pagine: 18 - 22
SICI:
0887-6924(1996)10:<18:AOBBBA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CELL-DEATH; GENE CED-3; APOPTOSIS; PROTEIN; PREVENTION; INDUCTION; ETOPOSIDE; BCL-X(L); ANTIGENS;
Keywords:
AML; BCL-2; BCL-XL; BAX; ICE; DRUG RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
O.J. Stoetzer et al., "ASSOCIATION OF BCL-2, BAX, BCL-XL AND INTEULEUKIN-1-BETA-CONVERTING ENZYME EXPRESSION WITH INITIAL RESPONSE TO CHEMOTHERAPY IN ACUTE MYELOID-LEUKEMIA", Leukemia, 10, 1996, pp. 18-22

Abstract

Bcl-2 expression is able to confer drug resistance to chemotherapy-induced programmed cell death. Bax, a partner protein of bcl-2 with extensive aminoacid homology, is a promoter of apoptosis. Apparently the equilibrium of bcl-2 and bax hetero- and homodimers is important for the susceptibility of cells for stimuli inducing apoptosis. In this study we determined the role of bcl-2 to bax expression ratio, bcl-xL and ICE expression level for predicting clinical response to chemotherapy in acute myeloid leukemia (AML). Bone marrow samples from 14 patients with AML were examined using an immunophosphatase staining method. Initial bone marrow blast portion was over 80% in all cases. Clinical response was defined by bone marrow aspiration 4 weeks after treatment initiation. There was a significant correlation between bcl-2 to bar expression ratio and clinical response (P < 0.005). No patients with a bcl-2/bax ratio > 1.0 achieved complete remission after induction therapy. No significant correlation between bcl-2- and p-glycoprotein-expression was observed in this group. Conversely a high expression of ICE indicated a good clinical response (P < 0.01), whereas expression of bcl-xL had no influence on therapeutic success in this group.

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Documento generato il 24/11/20 alle ore 11:25:56