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Titolo:
ABSENCE OF CIRCULATING ADRENAL AUTOANTIBODIES IN ADULT-ONSET X-LINKEDADRENOLEUKODYSTROPHY
Autore:
LAURETI S; FALORNI A; VOLPATO M; CASUCCI G; PICCHIO ML; ANGELETTI G; LUTHMAN H; BRUNETTI P; BETTERLE C; SANTEUSANIO F;
Indirizzi:
UNIV PERUGIA,DIPARTIMENTO MED INTERNA & SCI ENDOCRINE & METAB,VIA E DAL POZZO I-06126 PERUGIA ITALY KAROLINSKA INST,DEPT MOL MED STOCKHOLM SWEDEN UNIV PADUA,INST MED SEMEIOT I-35100 PADUA ITALY
Titolo Testata:
Hormone and Metabolic Research
fascicolo: 7, volume: 28, anno: 1996,
pagine: 319 - 322
SICI:
0018-5043(1996)28:7<319:AOCAAI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; STEROID-PRODUCING CELLS; SATURATED FATTY-ACIDS; ADDISONS-DISEASE; LONG-CHAIN;
Keywords:
ADRENOLEUKODYSTROPHY; ADRENAL INSUFFICIENCY; AUTOIMMUNITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S. Laureti et al., "ABSENCE OF CIRCULATING ADRENAL AUTOANTIBODIES IN ADULT-ONSET X-LINKEDADRENOLEUKODYSTROPHY", Hormone and Metabolic Research, 28(7), 1996, pp. 319-322

Abstract

X-linked adrenoleukodystrophy (ALD) is a frequent cause of adrenal insufficiency in young-adult patients with Addison's disease. As the contribution of an autoimmune process in the destruction of steroid cellsin ALD is unclear, the aim of the present study was to evaluate the occurrence of adrenal-, thyroid- and islet-specific and non organ-specific autoantibodies in adult ALD patients. In all 5 patients, Addison'sdisease was the first manifestation of ALD. None of the ALD patients were positive for adrenal cortex autoantibodies in an indirect immunofluorescence assay, or for 21-hydroxylase autoantibodies in a radiobinding assay with recombinant human antigen. Similarly, we found neither non-organ specific autoantibodies (such as anti-nuclear, anti-ribosomal, anti-mitochondria, anti-smooth-muscle, anti-liver/kidney microsomalor anti-reticulin autoantibodies), nor islet-cell antibodies or glutamic acid decarboxylase (GAD65 or GAD67) autoantibodies, nor thyroglobulin autoantibodies in the sera of the 5 ALD patients. Two out of five patients were positive for thyroid microsomal autoantibodies. One of the two latter thyroid antibody-positive patients had clinical symptomsof hypothyroidism, and the other presented high levels of circulatingTSH but no clinical signs or symptoms of hypothyroidism. Our study demonstrates that adult ALD is not immediately associated with the presence of adrenal autoantibodies and suggests that adrenal insufficiency is not mediated by an autoimmune process in adult ALD patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:00:03