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Titolo:
EFFECTS OF FK506 AND CYCLOSPORINE-A ON PROLIFERATION, HISTAMINE-RELEASE AND PHENOTYPE OF MURINE MAST-CELLS
Autore:
TOYOTA N; HASHIMOTO Y; MATSUO S; KITAMURA Y; IIZUKA H;
Indirizzi:
ASAHIKAWA MED COLL,DEPT DERMATOL,4-5-3-11 NISHIKAGURA ASAHIKAWA HOKKAIDO 078 JAPAN OSAKA UNIV,SCH MED,DEPT PATHOL OSAKA 530 JAPAN
Titolo Testata:
Archives of dermatological research
fascicolo: 8, volume: 288, anno: 1996,
pagine: 474 - 480
SICI:
0340-3696(1996)288:8<474:EOFACO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONNECTIVE-TISSUE-TYPE; CYTOSOLIC BINDING-PROTEIN; PEPTIDYL-PROLYL ISOMERASE; GROWTH-ENHANCING ACTIVITY; CIS-TRANS ISOMERASE; IMMUNOSUPPRESSANT FK506; MEDIATOR RELEASE; HUMAN BASOPHILS; CYCLOPHILIN; FK-506;
Keywords:
MAST CELLS; CYCLOSPORINE A; FK506;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
N. Toyota et al., "EFFECTS OF FK506 AND CYCLOSPORINE-A ON PROLIFERATION, HISTAMINE-RELEASE AND PHENOTYPE OF MURINE MAST-CELLS", Archives of dermatological research, 288(8), 1996, pp. 474-480

Abstract

Using mouse peritoneal cavity mast cells, we investigated the effectsof FK506 and cyclosporin A (CsA) on cell proliferation and histamine release induced by anti-IgE antibody, calcium ionophore (A23187), or neuropeptide (substance P). Both FK506 and CsA inhibited cytokine-dependent mast cell proliferation in a dose-dependent manner. The inhibitory effects of these compounds on mast cell proliferation was reversible; the removal of the chemicals from the incubation medium resulted in the reinitiation of mast cell proliferation, Flow cytometric analysis suggested that the inhibitory effect of FK506 and CsA was mostly due to G(1)/S boundary block, although a significant number of G(2)-arrested cells were also observed following FK506 treatment, Both FK506- and CsA-treated mast cells showed a similar inhibition of histamine release induced by A23187. However, CsA at higher concentrations inhibited the histamine release induced by anti-IgE antibody or substance P more markedly than FK506, Cellular histamine content was decreased by CsA treatment while FK506 had no effect, The staining properties of peritoneal mast cells changed from connective tissue-type mast cell-like to mucosal mast cell-like during CsA treatment but not during FK506 treatment, Thus FK506 and CsA have different effects on mast cell proliferation as well as histamine release, that might be associated with a phenotypic change of the cells during culture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 00:28:36