Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IGA ANTIKERATINOCYTE SURFACE AUTOANTIBODIES FROM 2 TYPES OF INTERCELLULAR IGA VESICULOPUSTULAR DERMATOSIS RECOGNIZE DISTINCT ISOFORMS OF DESMOCOLLIN
Autore:
HASHIMOTO T; EBIHARA T; DMOCHOWSKI M; KAWAMURA K; SUZUKI T; TSURUFUJI S; GARROD DR; NISHIKAWA T;
Indirizzi:
KEIO UNIV,SCH MED,DEPT DERMATOL,SHINJUKU KU,35 SHINANOMACHI TOKYO 160JAPAN INST CYTOSIGNAL RES INC,SHINAGAWA KU TOKYO 140 JAPAN UNIV MANCHESTER,SCH BIOL SCI,CRC,EPITHELIAL MORPHOGENESIS RES GRP MANCHESTER M13 9PT LANCS ENGLAND
Titolo Testata:
Archives of dermatological research
fascicolo: 8, volume: 288, anno: 1996,
pagine: 447 - 452
SICI:
0340-3696(1996)288:8<447:IASAF2>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCORNEAL PUSTULAR DERMATOSIS; PEMPHIGUS-VULGARIS ANTIGEN; CELL-ADHESION MOLECULES; GLYCOPROTEIN-3 DESMOCOLLINS; DESMOSOMAL GLYCOPROTEIN-2; EXTRACELLULAR DOMAIN; CYTOPLASMIC DOMAINS; EXPRESSION PATTERNS; FOLIACEUS; CADHERIN;
Keywords:
AUTOANTIBODY; DESMOCOLLIN; IMMUNOBLOT; IGA; PEMPHIGUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T. Hashimoto et al., "IGA ANTIKERATINOCYTE SURFACE AUTOANTIBODIES FROM 2 TYPES OF INTERCELLULAR IGA VESICULOPUSTULAR DERMATOSIS RECOGNIZE DISTINCT ISOFORMS OF DESMOCOLLIN", Archives of dermatological research, 288(8), 1996, pp. 447-452

Abstract

We previously proposed the term intercellular IgA vesiculopustular dermatosis (IAVPD) for cases showing IgA antikeratinocyte surface autoantibodies, This condition is divided into two subtypes: intraepidermal neutrophilic IgA dermatosis (IEN), showing pustule formation in the entire epidermis, and subcorneal pustular dermatosis (SPD) showing pustule formation in the uppermost epidermis, We have previously reported that serum from certain IAVPD patients reacts with bovine desmocollin (Dsc), a desmosomal cadherin, In this study we showed that two Dsc isoforms with a slightly different molecular weight were recognized by theserum from these patients, Further analysis revealed that serum from patients with the SPD type, which stained the cell surface in the uppermost epidermis with immunofluorescence, seem to react with Dsc1. By contrast, serum from patients with the IEN type, which stained the cellsurface at all levels of the epidermis with immunofluorescence, seemed to react with Dsc3, This difference of distribution between the two distinct Dsc molecules may contribute to the different clinicopathological features between the IEN and SPD type of IAVPD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:39:23