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Titolo:
SCHIZOSTATIN, A NOVEL SQUALENE SYNTHASE INHIBITOR PRODUCED BY THE MUSHROOM, SCHIZOPHYLLUM-COMMUNE .2. STRUCTURE ELUCIDATION AND TOTAL SYNTHESIS
Autore:
KOGEN H; TAGO K; KANEKO S; HAMANO K; ONODERA K; HARUYAMA H; MINAGAWA K; KINOSHITA T; ISHIKAWA T; TANIMOTO T; TSUJITA Y;
Indirizzi:
SANKYO CO LTD,EXPLORATORY CHEM RES LABS,1-2-58 HIROMACHI TOKYO 140 JAPAN SANKYO CO LTD,BIOMED RES LABS TOKYO 140 JAPAN SANKYO CO LTD,ANALYT & METAB RES LABS TOKYO 140 JAPAN SANKYO CO LTD,PHARMACOL & MOL BIOL RES LABS TOKYO 140 JAPAN
Titolo Testata:
Journal of antibiotics
fascicolo: 7, volume: 49, anno: 1996,
pagine: 624 - 630
SICI:
0021-8820(1996)49:7<624:SANSSI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TANDEM MASS-SPECTROMETRY; CARBONYL-COMPOUNDS; FATTY-ACIDS; LOCATION; ALLYLBARIUM; ALLYLATION; REAGENTS; METAL; BONDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
H. Kogen et al., "SCHIZOSTATIN, A NOVEL SQUALENE SYNTHASE INHIBITOR PRODUCED BY THE MUSHROOM, SCHIZOPHYLLUM-COMMUNE .2. STRUCTURE ELUCIDATION AND TOTAL SYNTHESIS", Journal of antibiotics, 49(7), 1996, pp. 624-630

Abstract

Schizostatin (1) has been isolated as a potent and selective inhibitor of squalene synthase. Its structure has been determined using spectroscopic methods: the compound is shown to be a diterpenoid which has atrans-dicarboxylic acid moiety. Total synthesis of schizostatin (1) was achieved by the highly regio- and stereoselective coupling reactionof an allylic bromide with a barium reagent. The 2-isomer 16 was alsoprepared using the stereoselective syn-addition of an organocopper reagent to acetylenedicarboxylate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 14:16:16