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Titolo:
SCHIZOSTATIN, A NOVEL SQUALENE SYNTHASE INHIBITOR PRODUCED BY THE MUSHROOM, SCHIZOPHYLLUM-COMMUNE .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES
Autore:
TANIMOTO T; ONODERA K; HOSOYA T; TAKAMATSU Y; KINOSHITA T; TAGO K; KOGEN H; FUJIOKA T; HAMANO K; TSUJITA Y;
Indirizzi:
SANKYO CO LTD,PHARMACOL & MOL BIOL RES LABS,1-2-58 HIROMACHI TOKYO 140 JAPAN SANKYO CO LTD,BIOMED RES LABS TOKYO 140 JAPAN SANKYO CO LTD,ANALYT & METAB RES LABS TOKYO 140 JAPAN SANKYO CO LTD,TSUKUBA RES LABS TSUKUBA IBARAKI 305 JAPAN
Titolo Testata:
Journal of antibiotics
fascicolo: 7, volume: 49, anno: 1996,
pagine: 617 - 623
SICI:
0021-8820(1996)49:7<617:SANSSI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
T. Tanimoto et al., "SCHIZOSTATIN, A NOVEL SQUALENE SYNTHASE INHIBITOR PRODUCED BY THE MUSHROOM, SCHIZOPHYLLUM-COMMUNE .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES", Journal of antibiotics, 49(7), 1996, pp. 617-623

Abstract

In the process of screening for squalene synthase inhibitors from microbial fermentation products we have isolated a novel compound, named schizostatin (Fig. 1), from the culture broth of the mushroom, Schizophyllum commune SANK 17785. Schizostatin inhibited rat liver microsomalsqualene synthase dose dependently and the IC50 value was 0.84 mu M. The inhibition was competitive with respect to farnesylpyrophosphate with a Ki value of 0.45 mu M.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:52:54