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Titolo:
SALUTARY AND PROPHYLACTIC EFFECT OF PENTADECAPEPTIDE BPC-157 ON ACUTE-PANCREATITIS AND CONCOMITANT GASTRODUODENAL LESIONS IN RATS
Autore:
SIKIRIC P; SEIWERTH S; GRABAREVIC Z; RUCMAN R; PETEK M; JAGIC V; TURKOVIC B; ROTKVIC I; MISE S; ZORICIC I; JURINA L; KONJEVODA P; HANZEVACKI M; LJUBANOVIC D; SEPAROVIC J; GJURASIN M; BRATULIC M; ARTUKOVIC B; JELOVAC N; BULJAT G;
Indirizzi:
UNIV ZAGREB,FAC MED,DEPT PHARMACOL,SALATA 11,POB 916 ZAGREB 10000 CROATIA UNIV ZAGREB,FAC MED & VET,CTR DIGEST DIS ZAGREB CROATIA
Titolo Testata:
Digestive diseases and sciences
fascicolo: 7, volume: 41, anno: 1996,
pagine: 1518 - 1526
SICI:
0163-2116(1996)41:7<1518:SAPEOP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE AGONISTS; DUODENAL-ULCER; RESTRAINT STRESS; BRAIN PEPTIDES; SOMATOSTATIN; ANTAGONISTS; ORGANOPROTECTION; CYTOPROTECTION; STOMACH; ETHANOL;
Keywords:
PENTADECAPEPTIDE BPC 157; ACUTE PANCREATITIS; GASTRODUODENAL LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
P. Sikiric et al., "SALUTARY AND PROPHYLACTIC EFFECT OF PENTADECAPEPTIDE BPC-157 ON ACUTE-PANCREATITIS AND CONCOMITANT GASTRODUODENAL LESIONS IN RATS", Digestive diseases and sciences, 41(7), 1996, pp. 1518-1526

Abstract

The superior effectiveness of a new pentadecapeptide, BPC 157, on gastrointestinal and liver lesions, in conjunction with an antiinflammatory and analgetic activity was recently noted. In the present study, BPC 157 was tested as either a protective or healing agent in bile duct ligation-induced acute pancreatitis in rats. In addition, the positiveinfluence of BPC 157 on concomitantly developed gastric and duodenal lesions was simultaneously investigated. BPC 157 (10 mu g, 10 ng/kg body wt, intraperitoneally or intragastrically) was given prophylactically 1 hr before ligation, whereas the therapy was given once daily beginning with the 24 hr following ligation (last application 24 hr beforekilling). The effect was investigated at daily intervals until the end of the fifth day after ligation. In the pretreatment regimen, a strong pancreas protection was obtained. When applied in the condition of already established severe acute pancreatitis, an obvious salutary effect was consistently noted. Assessing the appearance of the necrosis, edema, neutrophils, and mononuclears, consistently less necrosis, edema, and neutrophils, but more mononuclears, were found in BPC-treated rats. Likewise, in studies of the serum amylase values, relative to control data, a markedly lower rise (BPC pretreatment regimen) as well asa worsening of the already raised values (BPC therapy regimen) was noted. Along with its beneficial effect on pancreatitis, a positive influence of BPC 157 on the gastric and duodenal lesion course in bile duct-ligated rats was noted in both the pre- and posttreatment regimen. Taken together, in further studies of acute pancreatitis therapy, BPC could be an interesting and useful agent with an additional positive impact on concomitant gastroduodenal pathology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:55:39