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Titolo:
MUTATION ANALYSIS OF THE C-MOS PROTOONCOGENE AND THE ENDOTHELIN-B RECEPTOR GENE IN MEDULLARY-THYROID CARCINOMA AND PHEOCHROMOCYTOMA
Autore:
ENG C; FOSTER KA; HEALEY CS; HOUGHTON C; GAYTHER SA; MULLIGAN LM; PONDER BAJ;
Indirizzi:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CANC EPIDEMIOL & CONTROL,DEPT MED,M3A 31 BOSTON MA 02115 UNIV CAMBRIDGE,CRC,HUMAN CANC GENET RES GRP CAMBRIDGE CB2 2QQ ENGLAND QUEENS UNIV,DEPT PATHOL KINGSTON ON K7L 3N6 CANADA QUEENS UNIV,DEPT PAEDIAT KINGSTON ON K7L 3N6 CANADA
Titolo Testata:
British Journal of Cancer
fascicolo: 3, volume: 74, anno: 1996,
pagine: 339 - 341
SICI:
0007-0920(1996)74:3<339:MAOTCP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOCRINE NEOPLASIA TYPE-2; TYROSINE KINASE DOMAIN; RET PROTOONCOGENE; MEN 2A; POINT MUTATION; PHEOCHROMOCYTOMAS; FMTC; PHENOTYPE; DISEASE; 2B;
Keywords:
MEN 2; RET; C-MOS; ENDOTHELIN-B RECEPTOR; MEDULLARY THYROID CARCINOMA; PHEOCHROMOCYTOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Eng et al., "MUTATION ANALYSIS OF THE C-MOS PROTOONCOGENE AND THE ENDOTHELIN-B RECEPTOR GENE IN MEDULLARY-THYROID CARCINOMA AND PHEOCHROMOCYTOMA", British Journal of Cancer, 74(3), 1996, pp. 339-341

Abstract

The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic IWTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis ofthese tumours. We carried out direct sequence analysis of human c-mosand human ENRB in a series of sporadic MTC and phaeochromocytomas to determine if somatic mutations in these two genes could account for some of the sporadic MEN 2-related tumours in which no RET mutations aredetected. No somatic mutations were found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:51:11