Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTOR AND TARGET-CELLS IN THE ASSESSMENT OF NATURAL CYTOTOXIC ACTIVITY OF RHESUS-MONKEYS
Autore:
LUBACH GR; COE CL; KARASZEWSKI JW; ERSHLER WB;
Indirizzi:
UNIV WISCONSIN,WISCONSIN REG PRIMATE RES CTR,1223 CAPITOL COURT MADISON WI 53715 UNIV WISCONSIN,DEPT PSYCHOL MADISON WI 53715 UNIV WISCONSIN,HARLOW PRIMATE LAB MADISON WI 53715 UNIV WISCONSIN,SCH MED,DEPT MED MADISON WI 53715
Titolo Testata:
American journal of primatology
fascicolo: 4, volume: 39, anno: 1996,
pagine: 275 - 287
SICI:
0275-2565(1996)39:4<275:EATITA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONONUCLEAR LEUKOCYTES; KILLER-CELLS; GAMMA-DELTA; MATERNAL SEPARATION; PERIPHERAL-BLOOD; MEDIATED CYTOTOXICITY; NONHUMAN-PRIMATES; PEER SEPARATION; T-CELLS; LYMPHOCYTE SUBSETS;
Keywords:
NATURAL KILLER CELLS; LYMPHOCYTES; K562; RAJI; STRESS; MACACA MULATTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Lubach et al., "EFFECTOR AND TARGET-CELLS IN THE ASSESSMENT OF NATURAL CYTOTOXIC ACTIVITY OF RHESUS-MONKEYS", American journal of primatology, 39(4), 1996, pp. 275-287

Abstract

In humans, decreased natural killer cell (NK) activity has been associated with stressful life events, whereas acute arousal and disturbance frequently has been reported to result in increased NK activity. This bidirectional immune modulation prompted us to investigate the effects of a social stressor on the lymphocyte cytolytic activity of 31 infant rhesus monkeys. The first of three studies evaluated the effects of an 8 hr maternal separation on the infants' cytolytic response against the K562 target-cell line. A finding of increased lytic activity indicated a need for a longer evaluation-after a 24 hr separation-and anadditional assessment of two other target-cell lines, Raji and Daudi. The observation of decreased lytic responses to Raji and Daudi, in association with increased lysis of K562, warranted a third study to delineate which rhesus effector cells were responsible for lysis of the K562 and Raji target cells. By isolating cell subsets, it was possible to observe that the majority of unprimed cytotoxic activity resided inthe CD3- population of cells, but that the CD3+ CD8+ population also mediated a significant amount of cytotoxicity against both targets. Inconclusion, these findings support earlier studies indicating that maternal separation results in significant immune alterations in infant monkeys. However, the complex nature of changes in cytotoxic responsesduring prolonged stress revealed that different lymphocyte populations engage in parallel and compensatory alterations. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:07:41