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Titolo:
RETARDED ACQUISITION AND REDUCED EXPRESSION OF CONDITIONED LOCOMOTOR-ACTIVITY IN ADULT-RATS FOLLOWING REPEATED EARLY MATERNAL SEPARATION - EFFECTS OF PREFEEDING, D-AMPHETAMINE, DOPAMINE ANTAGONISTS AND CLONIDINE
Autore:
MATTHEWS K; HALL FS; WILKINSON LS; ROBBINS TW;
Indirizzi:
UNIV CAMBRIDGE,DEPT EXPTL PSYCHOL,DOWNING ST CAMBRIDGE CB2 3EB ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 126, anno: 1996,
pagine: 75 - 84
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIMOZIDE BLOCKS ESTABLISHMENT; PITUITARY-ADRENAL AXIS; NUCLEUS-ACCUMBENS; PREPARATORY BEHAVIOR; MESOLIMBIC DOPAMINE; MOTIVATED BEHAVIOR; GROWTH-HORMONE; INFANT RAT; DEPRIVATION; RELEASE;
Keywords:
MATERNAL SEPARATION; CONDITIONED INCENTIVE STIMULI; CONDITIONED LOCOMOTOR ACTIVITY; MESOLIMBIC DOPAMINE; AMPHETAMINE; SULPIRIDE; SCH 23390; CLONIDINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
K. Matthews et al., "RETARDED ACQUISITION AND REDUCED EXPRESSION OF CONDITIONED LOCOMOTOR-ACTIVITY IN ADULT-RATS FOLLOWING REPEATED EARLY MATERNAL SEPARATION - EFFECTS OF PREFEEDING, D-AMPHETAMINE, DOPAMINE ANTAGONISTS AND CLONIDINE", Psychopharmacology, 126(1), 1996, pp. 75-84

Abstract

Adult hooded rats exposed to a repeated maternal separation procedureduring the neonatal period showed a blunted expression of locomotor hyperactivity conditioned to the presentation of the daily food ration,We have demonstrated that the expression of food-conditioned anticipatory hyperactivity is sensitive to the response-enhancing effects of systemic d-amphetamine (0.5; 1.0 mg/kg) and to the response-attenuatingeffects of the selective dopamine D-2 antagonist sulpiride (8; 20 mg/kg), the selective dopamine D-1 antagonist SCH 23390 (0.01; 0.022 mg/kg) and the mixed alpha(1)/alpha(2) adrenoceptor agonist clonidine (5; 15 mu g/kg) in a dose dependent manner. Animals from the early separation groups showed a reduced enhancement of activity in response to 0.5mg/kg d-amphetamine and a greater attenuation of activity in responseto 8 mg/kg sulpiride and 5 mu g/kg clonidine. Female separated rats also exhibited an attenuated locomotor response to the unconditioned stimulant effects of 0.5 mg/kg systemic d-amphetamine. The experiments confirm that early maternal separation attenuates the response to conditioned appetitive cues in adult rats and implicate altered dopaminergic and noradrenergic function in the changes. It is possible that earlymaternal separation in the rat may offer a useful preparation for investigation of the neural substrates mediating affective development and affective psychopathology.

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Documento generato il 20/01/20 alle ore 16:16:15