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Titolo:
MR-IMAGING CHARACTERIZATION OF POSTISCHEMIC MYOCARDIAL DYSFUNCTION (STUNNED MYOCARDIUM) - RELATIONSHIP BETWEEN FUNCTIONAL AND PERFUSION ABNORMALITIES
Autore:
SZOLAR DH; SAEED M; WENDLAND MF; SAKUMA H; ROBERTS TPL; STISKAL MA; DERUGIN N; HIGGINS CB;
Indirizzi:
UNIV CALIF SAN FRANCISCO,SCH MED,DEPT RADIOL,505 PARNASSUS AVE,L308 SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT RADIOL SAN FRANCISCO CA 94143
Titolo Testata:
Journal of magnetic resonance imaging
fascicolo: 4, volume: 6, anno: 1996,
pagine: 615 - 624
SICI:
1053-1807(1996)6:4<615:MCOPMD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY DISEASE; REGIONAL CONTRACTILE FUNCTION; POSITRON EMISSION TOMOGRAPHY; BLOOD-FLOW; WALL-MOTION; INTRACORONARY STREPTOKINASE; INTRAVENOUS STREPTOKINASE; HIBERNATING MYOCARDIUM; SPATIAL MODULATION;
Keywords:
MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE CONTRAST MEDIA; MYOCARDIAL ISCHEMIA; MYOCARDIAL FUNCTION; MYOCARDIAL PERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
D.H. Szolar et al., "MR-IMAGING CHARACTERIZATION OF POSTISCHEMIC MYOCARDIAL DYSFUNCTION (STUNNED MYOCARDIUM) - RELATIONSHIP BETWEEN FUNCTIONAL AND PERFUSION ABNORMALITIES", Journal of magnetic resonance imaging, 6(4), 1996, pp. 615-624

Abstract

Stunned myocardium has been detected in patients treated successfullywith thrombolytic agents, The hypothesis of this study was that fast gradient echo (GRE) imaging could be used to characterize the regionalfunctional and perfusion abnormalities that are indicative of myocardial stunning, This study was designed to monitor and correlate the extent of wall thickness and perfusion abnormalities as determined by fast (segmented k space) cine and contrast enhanced GRE imaging, respectively. Dogs were subjected to left circumflex (LCX) coronary artery occlusion (15 min) followed by 30-minute reperfusion (n = 8), Perivascular now probes were used to continuously measure now in left anterior descending (LAD) and LCX coronary arteries, Short-axis inversion recovery prepared fast GRE and cine images were acquired at baseline, at occlusion, and at 1, 10, and 30 minutes of renew, Regional signal intensity and percent systolic wall thickening were determined at 26 equally spaced circumferential positions to compare the extent of functional and perfusion abnormalities, During occlusion and reperfusion, the ischemic region was demonstrated on contrast-enhanced images as a hypointense and hyperintense region, respectively, During occlusion, the extentof the perfusion defect (32% +/- 2% of the circumference of the equatorial slice) correlated closely (r = .74) with the extent of contractile dysfunction (35% +/- 2%). After reperfusion, there was transient recovery in the percent wall thickening (26% +/- 4% vs 36% +/- 4% normal), coinciding with the reactive hyperemic response, but this was followed by a significant decline in wall thickening at 10 minutes (19% +/-4%) and 30 minutes (12% +/- 2%), Fast MR imaging may be useful to monitor postischemic myocardial abnormalities after thrombolytic therapy and the response to pharmacologic interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:23:37