Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE ARTERIAL-WALL - A NEW PHARMACOLOGICAL AND THERAPEUTIC TARGET
Autore:
LAURENT S; VANHOUTTE P; CAVERO I; CHABRIER PE; DUPUIS B; ELGHOZI JL; HAMON G; JANIAK P; JUILLET Y; KHER A; KOEN R; MADONNA O; MAFFRAND JP; PRUNEAU D; THUILLEZ C;
Indirizzi:
BROUSSAIS UNIV HOSP,DEPT PHARMACOL,96 RUE DIDOT F-75674 PARIS FRANCE LAB SERVIER COURBEVOIE FRANCE LAB RHONE POULENC RHORER EVRY FRANCE INST HENRI BEAUFOUR F-91952 LES ULIS FRANCE CTR HOSP REG & UNIV LILLE,DEPT PHARMACOL LILLE FRANCE NECKER UNIV HOSP,DEPT PHARMACOL PARIS FRANCE LAB ROUSSEL ROMAINVILLE FRANCE LAB SERVIER SURESNES FRANCE LAB PHARMACIA PARIS FRANCE LAB ROCHE NEUILLY SUR SEINE FRANCE MERCK SHARP & DOHME RES LABS PARIS FRANCE SANOFI RECH F-31036 TOULOUSE FRANCE LAB FOURNIER DIJON FRANCE ROUEN UNIV HOSP,DEPT PHARMACOL ROUEN FRANCE
Titolo Testata:
Fundamental and clinical pharmacology
fascicolo: 3, volume: 10, anno: 1996,
pagine: 243 - 257
SICI:
0767-3981(1996)10:3<243:TA-ANP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; POTASSIUM CHANNEL OPENERS; CONGESTIVE HEART-FAILURE; SPONTANEOUSLY HYPERTENSIVE RATS; CONVERTING ENZYME-INHIBITION; EPICARDIAL CORONARY-ARTERIES; ENDOTHELIN RECEPTOR; NITRIC-OXIDE; L-ARGININE; ATHEROSCLEROTIC PLAQUE;
Keywords:
ANGIOTENSIN II RECEPTOR ANTAGONISTS; ATHEROSCLEROSIS; ENDOTHELIUM; ENDOTHELIN RECEPTOR ANTAGONISTS; NITRATES; NO DONORS; ARTERIAL REMODELING; POTASSIUM CHANNEL ACTIVATORS; PROTEOGLYCANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
96
Recensione:
Indirizzi per estratti:
Citazione:
S. Laurent et al., "THE ARTERIAL-WALL - A NEW PHARMACOLOGICAL AND THERAPEUTIC TARGET", Fundamental and clinical pharmacology, 10(3), 1996, pp. 243-257

Abstract

In recent years, two key concepts having numerous interrelationships were advanced for the understanding of various cardiovascular diseases: the ''endothelial dysfunction'' and the ''arterial remodelling''. Both endothelial dysfunction and arterial remodelling occur in various pathologies including essential hypertension, heart failure, atherosclerosis, restenosis after angioplasty, and pulmonary hypertension, and have modified the therapeutic approach by offering new pharmacological targets: specific receptors not only at the site of the vascular smooth muscle cells but also on the endothelial cells, growth factors that stimulate proliferation of smooth muscle, and receptors and enzymes ofthe extra-cellular matrix. Among the various substances under research, the present review will discuss angiotensin II receptor antagonists, endothelin receptor antagonists, nitrates-NO donors, potassium channel activators, and substances interfering with proteoglycans and othercomponents of the extra-cellular matrix.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:47:37