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Titolo:
CHRONIC INTRACEREBROVENTRICULAR COCAINE DIFFERENTIALLY AFFECTS PRODYNORPHIN GENE-EXPRESSION IN RAT HYPOTHALAMUS AND CAUDATE-PUTAMEN
Autore:
ROMUALDI P; DONATINI A; IZENWASSER S; COX BM; FERRI S;
Indirizzi:
UNIV BOLOGNA,DEPT PHARMACOL,IRNERIO 48 I-40126 BOLOGNA ITALY NIDA,ADDICT RES CTR,PSYCHOBIOL SECT BALTIMORE MD 21224 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL BETHESDA MD 20814
Titolo Testata:
Molecular brain research
fascicolo: 1, volume: 40, anno: 1996,
pagine: 153 - 156
SICI:
0169-328X(1996)40:1<153:CICDAP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; PHARMACOLOGY; STRIATUM; ABUSE;
Keywords:
COCAINE; CHRONIC INFUSION; GENE EXPRESSION; PRODYNORPHIN MESSENGER-RNA; RAT; HYPOTHALAMUS; CAUDATE-PUTAMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
P. Romualdi et al., "CHRONIC INTRACEREBROVENTRICULAR COCAINE DIFFERENTIALLY AFFECTS PRODYNORPHIN GENE-EXPRESSION IN RAT HYPOTHALAMUS AND CAUDATE-PUTAMEN", Molecular brain research, 40(1), 1996, pp. 153-156

Abstract

We investigated the effects of sustained administration of cocaine onthe regulation of prodynorphin gene expression in rat brain. Intracerebroventricular (i.c.v.) infusion of cocaine hydrochloride (30 mu g/day) for 7 days, by means of osmotic minipumps, elicited a significant 35% decrease of prodynorphin mRNA levels in rat hypothalamus and increase (22%) in caudate-putamen. At the same time and in the same animals,no significant changes were detected in the hippocampus or in the nucleus accumbens. These results indicate that continuously infused cocaine is able to modulate expression of the prodynorphin gene in oppositedirections or has no effect on prodynorphin expression, depending on the brain region analysed. Cocaine, as well as opiates, might activatespecific neuronal pathways, shared by different classes of drugs of abuse, involving, at least in part, the endogenous opioid system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:52:35