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Titolo:
CHEMOKINES - A SUPERFAMILY OF CHEMOTACTIC CYTOKINES
Autore:
SOZZANI S; LOCATI M; ALLAVENA P; VANDAMME J; MANTOVANI A;
Indirizzi:
IST RIC FARMACOL MARIO NEGRI,VIA ERITREA 62 I-20157 MILAN ITALY UNIV BRESCIA,DEPT BIOTECHNOL,SECT PATHOL & IMMUNOL BRESCIA ITALY CATHOLIC UNIV LEUVEN,REGA INST B-3000 LOUVAIN BELGIUM
Titolo Testata:
International journal of clinical & laboratory research
fascicolo: 2, volume: 26, anno: 1996,
pagine: 69 - 82
SICI:
0940-5437(1996)26:2<69:C-ASOC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE CHEMOATTRACTANT PROTEIN-1; MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE CELLS; PLATELET-ACTIVATING-FACTOR; HISTAMINE-RELEASING-FACTOR; IDIOPATHIC PULMONARY FIBROSIS; BLOOD MONONUCLEAR LEUKOCYTES; HUMAN INTERLEUKIN-8 RECEPTOR; AMINO-ACID ANALYSIS;
Keywords:
CHEMOKINES; CHEMOTAXIS; PATHOLOGY; SIGNAL TRANSDUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
166
Recensione:
Indirizzi per estratti:
Citazione:
S. Sozzani et al., "CHEMOKINES - A SUPERFAMILY OF CHEMOTACTIC CYTOKINES", International journal of clinical & laboratory research, 26(2), 1996, pp. 69-82

Abstract

Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of chemokines encompasses a large number of leukocyte populations, including monocytes, granulocytes, lymphocytes, NK and dendritic cells. Although the spectrum of action of chemokines largely overlaps? clear differences are still present. Chemokines play an important role in the recruitment of leukocytes atthe site of inflammation, allergic reaction and tumors. Available information on receptor usage by MCP-1 and related chemokines and signal transduction pathways is reviewed. The better understanding of signaling mechanisms will provide a new basis for the development of therapeutic strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:27:13