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Titolo:
THE ROLE OF PROTEOLYTIC CLEAVAGE OF VIRAL GLYCOPROTEINS IN THE PATHOGENESIS OF INFLUENZA-VIRUS INFECTIONS
Autore:
TASHIRO M; ROTT R;
Indirizzi:
NATL INST HLTH,DEPT VIROL 1,SHINJUKU KU,TOYAMA 1-23-1 TOKYO 162 JAPAN UNIV GIESSEN,INST VIROL D-35392 GIESSEN GERMANY
Titolo Testata:
Seminars in virology
fascicolo: 4, volume: 7, anno: 1996,
pagine: 237 - 243
SICI:
1044-5773(1996)7:4<237:TROPCO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBTILISIN-LIKE ENDOPROTEASE; SENDAI VIRUS; A VIRUS; CHICK-EMBRYO; HEMAGGLUTININ ACTIVATION; FUSION GLYCOPROTEIN; TRYPTASE CLARA; FACTOR-X; PROTEASE; PATHOGENICITY;
Keywords:
PROTEASES; INFLUENZA VIRUS; PROTEOLYTIC CLEAVAGE; PATHOGENICITY; VIRAL GLYCOPROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
M. Tashiro e R. Rott, "THE ROLE OF PROTEOLYTIC CLEAVAGE OF VIRAL GLYCOPROTEINS IN THE PATHOGENESIS OF INFLUENZA-VIRUS INFECTIONS", Seminars in virology, 7(4), 1996, pp. 237-243

Abstract

Infectivity, tropism, spread, and pathogenicity of influenza viruses are based on the interplay between the fusogenic glycoproteins and appropriate host endoproteases. The hemagglutinin (HA) of influenza A andB viruses and the HEF (hemagglutinating; esterase, fusion) glycoprotein of influenza C virus receive their full biological activity by proteolytic cleavage of a precursor molecule at a definite cleavage site. The amino acid motifs at the cleavage site and the availability of suitable proteases are critical for the clinical manifestation of the infection. Prototype cleavage proteases, including bacterial enzymes, aredescribed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:01:02