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Titolo:
AIRWAY FUNCTION CORRELATES WITH CIRCULATING EOSINOPHIL, BUT NOT MAST-CELL, MARKERS OF INFLAMMATION IN CHILDHOOD ASTHMA
Autore:
RAO R; FREDERICK JM; ENANDER I; GREGSON RK; WARNER JA; WARNER JO;
Indirizzi:
SOUTHAMPTON GEN HOSP SOUTHAMPTON SO16 6YD HANTS ENGLAND PHARMACIA AB S-75182 UPPSALA SWEDEN
Titolo Testata:
Clinical and experimental allergy
fascicolo: 7, volume: 26, anno: 1996,
pagine: 789 - 793
SICI:
0954-7894(1996)26:7<789:AFCWCE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE; BRONCHIAL INFLAMMATION; SYSTEMIC-ANAPHYLAXIS; ALLERGEN CHALLENGE; GRANULE PROTEINS; ACTIVATION; CHILDREN; SERUM; TRYPTASE; RELEASE;
Keywords:
ASTHMA; SPIROMETRY; EOSINOPHIL PROTEINS; ECP; EPX; TRYPTASE; HISTAMINE CHALLENGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R. Rao et al., "AIRWAY FUNCTION CORRELATES WITH CIRCULATING EOSINOPHIL, BUT NOT MAST-CELL, MARKERS OF INFLAMMATION IN CHILDHOOD ASTHMA", Clinical and experimental allergy, 26(7), 1996, pp. 789-793

Abstract

Background Lung function tests, including forced expiratory volume inone second (FEV(1)), forced expiratory flow at 25-75% of vital capacity (FEF(25-75%)) and provocation concentrations of histamine which reduce FEV(1) by 20% (PC20), are used as indicators of airway form and function in bronchial asthma. Recently, markers of eosinophil activationin bronchial lavage and serum have been suggested as a measure of eosinophil mediated inflammation in the airways. These include eosinophilcationic protein (ECP), eosinophil protein X (EPX) (also known as eosinophil derived neurotoxin) and eosinophil peroxidase (EPO). Similarly, serum tryptase has been used as a marker of mast cell activation in systemic anaphylaxis. Objectives We measured both sets of indices in agroup of children with moderately severe asthma to assess the contribution of eosinophil and mast cell mediated events to airflow limitation and bronchial hyperresponsiveness. Methods Forty-eight children aged5-10 years had spirometric assessments, histamine challenges and blood sampling on the same occasion. After analysis of sera, the indices were compared. Results The eosinophil markers ECP and EPX correlated very well with each other. They showed a moderate negative correlation with PC20 for histamine. EPX was also found to negatively correlate with FEV(1) and FEF(25-75%) Serum tryptase levels showed no such correlates with airway function. Conclusion These results suggest that serum markers of eosinophil activation correlate with airway function in childhood asthma, and may be of value in assessing the severity of the disease. It further supports the notion that childhood asthma has a similar immunopathology to that occurring in adults, with predominance of eosinophil mediated inflammation.

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Documento generato il 27/01/21 alle ore 01:37:55