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Titolo:
HYPERHOMOCYST(E)INEMIA - AN INDEPENDENT R ISK FACTOR FOR STROKE
Autore:
LALOUSCHEK W; AULL S; DEECKE L; SCHNIDER P; UHL F; ZEILER K;
Indirizzi:
UNIV VIENNA,NEUROL KLIN,WAHRINGER GURTEL 18-20 A-1097 VIENNA AUSTRIA
Titolo Testata:
Fortschritte der Neurologie, Psychiatrie
fascicolo: 7, volume: 64, anno: 1996,
pagine: 271 - 277
SICI:
0720-4299(1996)64:7<271:H-AIRI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
GER
Soggetto:
CORONARY-ARTERY DISEASE; ELEVATED PLASMA HOMOCYST(E)INE; BETA-SYNTHASE DEFICIENCY; ISCHEMIC-HEART-DISEASE; VASCULAR-DISEASE; FOLIC-ACID; TOTAL HOMOCYSTEINE; MYOCARDIAL-INFARCTION; FOLATE-DEFICIENCY; HOMOCYSTINURIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
W. Lalouschek et al., "HYPERHOMOCYST(E)INEMIA - AN INDEPENDENT R ISK FACTOR FOR STROKE", Fortschritte der Neurologie, Psychiatrie, 64(7), 1996, pp. 271-277

Abstract

The total of free and protein-bound homocysteine including its derivatives is usually summarised as ''homocyst(e)ine [H(e)]''. Several congenital enzyme deficiencies may cause markedly elevated H(e) plasma levels, leading to the well-known clinical syndromes of homocystinuria. Recently, mild hyperhomocyst(e)inemia has been recognised as an independent risk factor for ischaemic cerebrovascular disease, coronary heartdisease, and peripheral artery disease. H(e) levels are also related to the extent of atherosclerotic vessel wall alterations. The role of mild hyperhomocyst(e)inemia in venous thromboembolic disease, however,is not yet clear. A considerable proportion of patients with mild hyperhomocyst(e)inemia suffers from a deficiency of folate, vitamin B-12,and/or vitamin B-6. Supplementation of these agents - alone or combined with betain - leads to a decrease or even to a normalisation of elevated H(e) levels in the majority of such patients. Hitherto, no prospective randomised studies dealing with the clinical efficacy of such a- probably innocuous - supplementation have been performed. In the meantime, adequate alimentary intake of folate should be ensured.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:36:18