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Titolo:
LIPASE-CATALYZED KINETIC RESOLUTION OF 3-HYDROXY ESTERS IN ORGANIC-SOLVENTS AND SUPERCRITICAL CARBON-DIOXIDE
Autore:
CAPEWELL A; WENDEL V; BORNSCHEUER U; MEYER HH; SCHEPER T;
Indirizzi:
UNIV STUTTGART,INST TECH BIOCHEM,ALLMANDRING 31 D-70569 STUTTGART GERMANY UNIV STUTTGART,INST TECH BIOCHEM D-70569 STUTTGART GERMANY UNIV HANNOVER,INST TECH CHEM D-3000 HANNOVER GERMANY UNIV HANNOVER,INST ORGAN CHEM D-3000 HANNOVER GERMANY
Titolo Testata:
Enzyme and microbial technology
fascicolo: 3, volume: 19, anno: 1996,
pagine: 181 - 186
SICI:
0141-0229(1996)19:3<181:LKRO3E>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSESTERIFICATION;
Keywords:
3-HYDROXY ESTERS; KINETIC RESOLUTION; LIPASE; ORGANIC SOLVENTS; PSEUDOMONAS CEPACIA; SUPERCRITICAL CARBON DIOXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
A. Capewell et al., "LIPASE-CATALYZED KINETIC RESOLUTION OF 3-HYDROXY ESTERS IN ORGANIC-SOLVENTS AND SUPERCRITICAL CARBON-DIOXIDE", Enzyme and microbial technology, 19(3), 1996, pp. 181-186

Abstract

The lipase-catalyzed kinetic resolution of different 3-hydroxy estersin organic solvents and supercritical carbon dioxide (SCCO2) was studied. Similar enantiomeric excesses (ee, up to 99%) as found for transesterifications in organic solvents were achieved also in SCCO2. The influence of various reaction parameters was investigated for the resolution of 3-hydroxy octanoic acid methyl esters with lipase from Pseudomonas cepacia in SCCO2. Optimum conditions have been found at 110 bar 40 degrees C, and in the presence of 1.5 g molecular sieve by using vinyl acetate as acyl donor. The addition of different cosolvents had only a small effect on the reaction. Immobilization of the lipase on VA-epoxy resulted in similar optical purities as found for the crude lipase, but at halved reaction times. The effect of supercritical conditions on the stability of the lipase was also investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:28:31