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Titolo:
ADAPTIVE RESISTANCE TO TOBRAMYCIN IN PSEUDOMONAS-AERUGINOSA LUNG INFECTION IN CYSTIC-FIBROSIS
Autore:
BARCLAY ML; BEGG EJ; CHAMBERS ST; THORNLEY PE; PATTEMORE PK; GRIMWOOD K;
Indirizzi:
CHRISTCHURCH HOSP,DEPT CLIN PHARMACOL CHRISTCHURCH NEW ZEALAND CHRISTCHURCH HOSP,DEPT INFECT DIS CHRISTCHURCH NEW ZEALAND CHRISTCHURCH HOSP,DEPT RESP MED CHRISTCHURCH NEW ZEALAND CHRISTCHURCH HOSP,DEPT PAEDIAT CHRISTCHURCH NEW ZEALAND UNIV MELBOURNE,DEPT PAEDIAT PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Journal of antimicrobial chemotherapy
fascicolo: 6, volume: 37, anno: 1996,
pagine: 1155 - 1164
SICI:
0305-7453(1996)37:6<1155:ARTTIP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINOGLYCOSIDE ANTIBIOTICS; AEROSOLIZED TOBRAMYCIN; EXOENZYME EXPRESSION; GENTAMICIN; SPUTUM; EFFICACY; THERAPY; NETILMICIN; BINDING; MACROMOLECULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Barclay et al., "ADAPTIVE RESISTANCE TO TOBRAMYCIN IN PSEUDOMONAS-AERUGINOSA LUNG INFECTION IN CYSTIC-FIBROSIS", Journal of antimicrobial chemotherapy, 37(6), 1996, pp. 1155-1164

Abstract

Aminoglycoside antibiotics have been shown to induce adaptive resistance in Pseudomonas aeruginosa in vitro and in a mouse model of infection, but adaptive resistance has not been described in human infections. Seven patients with cystic fibrosis were treated with inhaled tobramycin to determine whether adaptive resistance occurred in P. aeruginosa in their sputum. In three patients who had not recently taken antibiotics, 80 mg tobramycin was administered by nebuliser and resulting peak sputum tobramycin concentrations were 90-240 mg/L (elimination half-life 1.9-2.1 h). Adaptive resistance was detected in P. aeruginosa 1-4 h after the dose of tobramycin. Moderate resistance was present at 24 h and full susceptibility returned between 24 and 48 h. In four other patients on long-term twice-daily inhaled aminoglycoside treatment, adaptive resistance was present before, and 4 h after, 80 mg of tobramycin administered by nebuliser. The presence and time course of adaptive resistance in humans may have implications for improving aminoglycoside dosing regimens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 17:59:53