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Titolo:
NOVEL DIFFUSION CELL FOR IN-VITRO TRANSDERMAL PERMEATION, COMPATIBLE WITH AUTOMATED DYNAMIC SAMPLING
Autore:
BOSMAN IJ; LAWANT AL; AVEGAART SR; ENSING K; DEZEEUW RA;
Indirizzi:
UNIV GRONINGEN,CTR PHARM,DEPT ANALYT CHEM & TOXICOL,GRONINGEN INST DRUG STUDIES,A DEUSINGLAAN 2 NL-9713 AW GRONINGEN NETHERLANDS
Titolo Testata:
Journal of pharmaceutical and biomedical analysis
fascicolo: 8-10, volume: 14, anno: 1996,
pagine: 1015 - 1023
SICI:
0731-7085(1996)14:8-10<1015:NDCFIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLOW-THROUGH; SKIN; PENETRATION; ABSORPTION; MODEL;
Keywords:
ASPEC SYSTEM; ATROPINE; AUTOMATED DYNAMIC SAMPLING; DIFFUSION CELL; IN VITRO; KELDER CELL; SILASTIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
I.J. Bosman et al., "NOVEL DIFFUSION CELL FOR IN-VITRO TRANSDERMAL PERMEATION, COMPATIBLE WITH AUTOMATED DYNAMIC SAMPLING", Journal of pharmaceutical and biomedical analysis, 14(8-10), 1996, pp. 1015-1023

Abstract

The development of a new diffusion cell for in vitro transdermal permeation is described. The so-called Kelder cells were used in combination with the ASPEC system (Automatic Sample Preparation with ExtractionColumns), which is designed for the automation of solid-phase extractions (SPE). Instead of SPE columns, 20 Kelder cells were placed in theracks. This allowed automatic sampling of up to 20 cells for 24 h in a dynamic mode. The cells consist of an inlet compartment, a donor compartment and a receptor compartment. The size and the depth of the inlet compartment were important to avoid entrapment of air bubbles in the receptor compartment. The Kelder cells mimic blood flow beneath the skin by replacement of the permeating drug every 2 min. Hence sink conditions are more easily maintained than with the static Franz diffusion cell. The performance of the cells was tested with permeation experiments using atropine as a model drug permeating through an artificial membrane (Silastic). The use of this skin model minimized the variability in permeation of atropine as compared with human skin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 19:55:17