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Titolo:
NEUROPROTECTIVE (-SIDE CHAIN() 3S, 4S CANNABINOIDS WITH MODIFIED 5')
Autore:
POP E; BROWNE CE; NADLER V; BIEGON A; BREWSTER ME;
Indirizzi:
PHARMOS CORP,2 INNOVAT DR ALACHUA FL 32615 KIRIAT WEIZMANN SCI PK IL-76326 REHOVOT ISRAEL
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 13, volume: 6, anno: 1996,
pagine: 1553 - 1558
SICI:
0960-894X(1996)6:13<1553:N(C34C>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR; HU-211; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E. Pop et al., "NEUROPROTECTIVE (-SIDE CHAIN() 3S, 4S CANNABINOIDS WITH MODIFIED 5')", Bioorganic & medicinal chemistry letters, 6(13), 1996, pp. 1553-1558

Abstract

The synthesis and evaluation of two novel cannabinoids belonging to the (+) 3S, 4S nonpsychotropic series are described These derivatives bind to the NMDA receptor but have lower affinities than dexanabinol (HU-211), the series benchmark. The novel compounds protect neurons against NMDA-induced toxicity in cortical cell cultures and have lower toxicity to host neurons than dexanabinol. Copyright (C) 1996 Elsevier Science Ltd

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:22:37