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Titolo:
STUDIES OF THE C-HARVEY-RAS GENE IN PSYCHIATRIC-DISORDERS
Autore:
COMINGS DE; WU SJ; CHIU C; MUHLEMAN D; SVERD J;
Indirizzi:
CITY HOPE NATL MED CTR,DEPT MED GENET,1500 E DUARTE RD DUARTE CA 91010 SAGAMORE CHILDRENS HOSP DIX HILLS NY 11746
Titolo Testata:
Psychiatry research
fascicolo: 1, volume: 63, anno: 1996,
pagine: 25 - 32
SICI:
0165-1781(1996)63:1<25:SOTCGI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOURETTE-SYNDROME; INFANTILE-AUTISM; HA-RAS-1 ALLELES; SUBSTANCE-ABUSE; CANCER-PATIENTS; ADHD PROBANDS; CARCINOMA; HYPERACTIVITY; POLYMORPHISM; ASSOCIATION;
Keywords:
AUTISM; TOURETTES SYNDROME; ATTENTION DEFICIT HYPERACTIVITY DISORDER; SCHIZOPHRENIA; GENETICS; OBSESSIVE-COMPULSIVE AND PHOBIC SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Comings et al., "STUDIES OF THE C-HARVEY-RAS GENE IN PSYCHIATRIC-DISORDERS", Psychiatry research, 63(1), 1996, pp. 25-32

Abstract

Herault et al. (1993) previously reported a significant association between autism and the larger fragments of the c-Harvey-Ras (HRAS) Bam H1 polymorphism. We have sought to verify this finding and determine if there was any evidence for an association with other psychiatric disorders. Because of its greater sensitivity, we have examined the HRAS Msp I polymorphism. We found a just significant increase in the prevalence of the > 2.1 kb alleles in 48 subjects with autism versus 50 control subjects. There was no increase in the prevalence of the > 2.1 kb alleles in 164 probands with Tourette's syndrome. Examination of 16 preselected symptom clusters, however, showed a significant trend towardhigher scores for obsessive-compulsive and phobic symptoms in > 2.1 kb homozygotes. While this locus requires further study, in conjunctionwith the results of Herault et al., the present findings suggest thatgenetic defects in HRAS, and possibly other components of the G protein secondary messenger system, may play a role in some psychiatric disorders.

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Documento generato il 28/11/20 alle ore 09:24:03