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Titolo:
CHANGES IN THE SEROTONIN TRANSPORTER IN THE HIPPOCAMPUS OF SUBJECTS WITH SCHIZOPHRENIA IDENTIFIED USING [H-3] PAROXETINE
Autore:
NAYLOR L; DEAN B; OPESKIN K; PAVEY G; HILL C; KEKS N; COPOLOV D;
Indirizzi:
MENTAL HLTH RES INST VICTORIA,REBECCA L COOPER RES LABS,LOCKED BAG 11PARKVILLE VIC 3052 AUSTRALIA ROYAL PK PSYCHIAT HOSP,NATL HLTH & MRC SCHIZOPHRENIA RES UNIT PARKVILLE VIC AUSTRALIA VICTORIAN INST FORENS PATHOL S MELBOURNE VIC AUSTRALIA ALFRED HOSP,DEPT PSYCHIAT PRAHRAN VIC 3181 AUSTRALIA
Titolo Testata:
Journal of neural transmission
fascicolo: 6, volume: 103, anno: 1996,
pagine: 749 - 757
SICI:
0300-9564(1996)103:6<749:CITSTI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; NEURONAL MEMBRANES; FRONTAL-CORTEX; RECEPTORS; BRAIN; PLATELET; AFFINITY;
Keywords:
[H-3] PAROXETINE; HIPPOCAMPUS; SCHIZOPHRENIA; NEUROLEPTIC DRUGS; SUICIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
L. Naylor et al., "CHANGES IN THE SEROTONIN TRANSPORTER IN THE HIPPOCAMPUS OF SUBJECTS WITH SCHIZOPHRENIA IDENTIFIED USING [H-3] PAROXETINE", Journal of neural transmission, 103(6), 1996, pp. 749-757

Abstract

[H-3]paroxetine binding to membrane from hippocampus, obtained at autopsy, from 24 schizophrenic and 24 non-schizophrenic subjects has beenmeasured. The affinity of [H-3]paroxetine binding to hippocampal membrane was decreased in subjects with schizophrenia (Kd = 0.50 +/- 0.04 vs. 0.24 +/- 0.02nM; mean +/- S.E.M. p < 0.001) but was not different in schizophrenic subjects who had or had not committed suicide (Kd = 0.50 +/- 0.07 vs. 0.50 +/- 0.04nM). The density of [H-3]paroxetine binding sites did not differ between the schizophrenic and non-schizophrenic subjects. For the schizophrenic subjects, there was no relationshipbetween ante-mortem neuroleptic drug treatment and [H-3]paroxetine binding to the hippocampal membrane. Finally, this study has shown that neuroleptic drug treatment of rats does not alter [H-3]paroxetine binding to the hippocampal membranes. Thus, it would seem that the changesin the affinity of [H-3]paroxetine binding to the hippocampus of schizophrenic subjects are not likely to be due to neuroleptic drug treatment but may be involved in the pathology of the illness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:51:53