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Titolo:
COMPARISON OF CENTRALIZED VERSUS SITE-BASED MEASUREMENT OF ANGIOGRAPHIC STENOSIS FOR ELIGIBILITY IN THE ASYMPTOMATIC CAROTID ATHEROSCLEROSIS STUDY
Autore:
DEAN BL; LEFKOWITZ DS; HOWARD VJ; FREY JF; SCHWARTZ S; CHAMBLESS LE; HEISERMAN JE; FEINBERG WM; TOOLE JF;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,MED CTR,DEPT NEUROL,STROKE RES CTR,EDITORIAL OFF WINSTON SALEM NC 27157 ST JOSEPH HOSP & MED CTR,BARROW NEUROL INST PHOENIX AZ 00000 UNIV S FLORIDA,COLL PUBL HLTH,DEPT BIOSTAT & EPIDEMIOL TAMPA FL 00000 UNIV N CAROLINA,DEPT BIOSTAT CHAPEL HILL NC 00000 UNIV ARIZONA,HLTH SCI CTR,STROKE RES LAB TUCSON AZ 00000
Titolo Testata:
Investigative radiology
fascicolo: 7, volume: 31, anno: 1996,
pagine: 446 - 450
SICI:
0020-9996(1996)31:7<446:COCVSM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASSESSING OBSERVER VARIABILITY; 1001 ANGIOGRAMS; REPRODUCIBILITY; ENDARTERECTOMY; EFFICACY; TRIALS; ISSUES;
Keywords:
CAROTID STENOSIS; ANGIOGRAPHY; MULTICENTER CLINICAL TRIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Dean et al., "COMPARISON OF CENTRALIZED VERSUS SITE-BASED MEASUREMENT OF ANGIOGRAPHIC STENOSIS FOR ELIGIBILITY IN THE ASYMPTOMATIC CAROTID ATHEROSCLEROSIS STUDY", Investigative radiology, 31(7), 1996, pp. 446-450

Abstract

RATIONALE AND OBJECTIVES. The authors determine the reliability of centralized versus noncentralized (site-based) measurement of angiographic stenosis of patients enrolled into the multicenter, prospective, Asymptomatic Carotid Atherosclerosis Study by angiographic studies, METHODS. Percent agreements and correlations of 244 masked and prospectively interpreted angiograms were calculated for comparison of centralized and noncentralized readers measuring the percent carotid stenosis from the same angiographic studies, Univariate summary statistics for differences in percent stenoses were calculated for these readings, RESULTS. Agreement between readings were 88.5% and 91.8% with kappa statistics of 0.77 and 0.73 for greater than or equal to 60% and greater than or equal to 80% stenosis, respectively, for comparison of 33 centersto the designated central reader, Comparison between the designated central reader and a second central reader derived percent agreements of 85.0% and 86.5% with kappa statistics of 0.69 and 0.41 for greater than or equal to 60% and greater than or equal to 80% stenoses, respectively, for arteries selected from the original group, Hence, agreementwas slightly better between the enrolling centers and the designated central reader than between the two central readers, CONCLUSIONS. Bothcentralized and noncentralized (site-based) methods of angiographic measurement of stenosis are equally reliable for large, prospective, masked, multicenter trials when quality control measures are instituted to ensure uniform application of eligibility criteria.

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Documento generato il 27/11/20 alle ore 02:27:48