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Titolo:
MONOCYTE FUNCTION-ASSOCIATED WITH INTERMITTENT LENTINAN THERAPY AFTERRESECTION OF GASTRIC-CANCER
Autore:
TAKESHITA K; HAYASHI S; TANI M; KANDO F; SAITO N; ENDO M;
Indirizzi:
TOKYO MED & DENT UNIV,SCH MED,DEPT SURG 1,BUNKYO KU,1-5-45 YUSHIMA TOKYO 113 JAPAN
Titolo Testata:
Surgical oncology
fascicolo: 1, volume: 5, anno: 1996,
pagine: 23 - 28
SICI:
0960-7404(1996)5:1<23:MFWILT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION; COMPLEMENT; INDUCTION;
Keywords:
GASTRIC CANCER PATIENTS; IL-1-BETA PRODUCTION; IMMUNOPOTENTIATING ACTION; LENTINAN ADMINISTRATION; SURGICAL ADJUVANT IMMUNOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
K. Takeshita et al., "MONOCYTE FUNCTION-ASSOCIATED WITH INTERMITTENT LENTINAN THERAPY AFTERRESECTION OF GASTRIC-CANCER", Surgical oncology, 5(1), 1996, pp. 23-28

Abstract

The effect of lentinan administration on monocyte function in the peripheral blood were examined in 33 patients who underwent resection of gastric cancer. As parameters of monocyte function, IL-1 production, C3b receptor, Fc gamma receptor and monocyte ratio were determined every 4 weeks for a maximum of 24 weeks. Among patients who were taking combined therapy with lentinan, an increase in IL-1 beta production of more than 50% was found 8 weeks (2 months) after the initiation of therapy in 8 of 12 patients given 2 mg at 2-week intervals, and in 11 of 16 patients given the same dose at 4-week intervals. This increase was particularly clear in stage II or more advanced cases. There were no significant changes in the other parameters studied. It has been considered that lentinen is effective when administered once a week. The results of the present study, however, suggest that lentinan given every 4 weeks also stimulates monocyte function enough to maintain immunological activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 16:10:35