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Titolo:
DEXAMETHASONE REDUCED CLONIDINE-INDUCED HYPOACTIVITY IN MICE
Autore:
CAPASSO A; DIGIANNUARIO A; LOIZZO A; PIERETTI S; SORRENTINO L;
Indirizzi:
UNIV SALERNO,SCH PHARM,PIAZZA VITTORIO EMANUELE 9 I-84084 PENTA DI FISCIANO SALERNO ITALY IST SUPER SANITA I-00161 ROME ITALY UNIV NAPLES FEDERICO II,DEPT EXPTL PHARMACOL I-80131 NAPLES ITALY
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 6, volume: 48, anno: 1996,
pagine: 615 - 618
SICI:
0022-3573(1996)48:6<615:DRCHIM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; ANTINOCICEPTIVE ACTIVITY; RECEPTOR SYSTEMS; ALPHA-2-ADRENOCEPTORS; GLUCOCORTICOIDS; CORTICOSTERONE; ADRENOCEPTORS; MECHANISMS; MORPHINE; RU-486;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Capasso et al., "DEXAMETHASONE REDUCED CLONIDINE-INDUCED HYPOACTIVITY IN MICE", Journal of Pharmacy and Pharmacology, 48(6), 1996, pp. 615-618

Abstract

Reduced clonidine anti-nociception in mice given low doses of dexamethasone has encouraged us to investigate the effects of dexamethasone pretreatment on locomotor hypoactivity, another example of clonidine-induced behaviour in mice. Dexamethasone administered intraperitoneally (0.1, 1.0, 10 mg kg(-1)) 30 min before clonidine reduced clonidine-induced locomotor hypoactivity in the activity cage to an extent which was dose-dependent. Dexamethasone administered centrally (10 ng/mouse) 30 min before clonidine was also able to reduce clonidine-induced locomotor hypoactivity. Cycloheximide administered at a dose of 10 mg kg(-1) 2 h before clonidine did not change the effects of clonidine but wasable to prevent the effects of dexamethasone on clonidine-induced hypoactivity. The glucocorticoid receptor antagonist RU38486 administeredcentrally at the dose of 1 ng/mouse did not change the effects of clonidine, whereas it was able to block the effects of dexamethasone on clonidine-induced locomotor hypoactivity. These results suggest that the effects of dexamethasone on clonidine-induced locomotor hypoactivitydepend on the stimulating effects that dexamethasone exerts on the protein synthesis via the glucocorticoid receptor in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:42:07