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Titolo:
AN ELECTROMYOGRAPHIC MARKER FOR NEUROLEPTIC-INDUCED AKATHISIA - PRELIMINARY MEASURES OF SENSITIVITY AND SPECIFICITY
Autore:
CUNNINGHAM SL; WINKELMAN JW; DORSEY CM; LUKAS SE; RICHARDSON GS; SHOLAR MB; HUNT A;
Indirizzi:
DIGITRACE CARE SERV,CLIN SLEEP SERV,286 CONGRESS ST BOSTON MA 02210 MCLEAN HOSP,SLEEP DISORDERS CTR BELMONT MA 02178 MCLEAN HOSP,SLEEP RES PROGRAM BELMONT MA 02178 MCLEAN HOSP,ALCOHOL & DRUG ABUSE RES CTR BELMONT MA 02178 HARVARD UNIV,SCH MED,DEPT PSYCHIAT BOSTON MA 02115 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED BOSTON MA 02115 HARVARD UNIV,SCH PUBL HLTH BOSTON MA 02115
Titolo Testata:
Clinical neuropharmacology
fascicolo: 4, volume: 19, anno: 1996,
pagine: 321 - 332
SICI:
0362-5664(1996)19:4<321:AEMFNA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARDIVE-DYSKINESIA; DRUGS;
Keywords:
NEUROLEPTIC-INDUCED AKATHISIA; ELECTROMYOGRAPHY; POLYSOMNOGRAPHY; CHLORPROMAZINE EQUIVALENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Cunningham et al., "AN ELECTROMYOGRAPHIC MARKER FOR NEUROLEPTIC-INDUCED AKATHISIA - PRELIMINARY MEASURES OF SENSITIVITY AND SPECIFICITY", Clinical neuropharmacology, 19(4), 1996, pp. 321-332

Abstract

Previous polysomnographic (PSG) investigations have reported a rhythmic electromyographic (EMG) pattern (0.5-3.0 cps) of leg movement activity in a subset of patients with neuroleptic-induced akathisia (NIA). It has been suggested that this EMG pattern may represent a pathophysiological correlate of NIA and thus have clinical utility as an objective marker for this condition. We present preliminary measures of sensitivity and specificity for this EMG pattern as a diagnostic marker forNIA for 26 neuroleptic-treated patients. The EMG marker yielded a diagnostic sensitivity of 68.9% and a specificity of 70.0%, falling just short of statistical significance (Fisher's exact test p = 0.06). Quantitative analysis of the EMG pattern revealed a significant positive correlation between the percentage of time the NIA marker occurred during wakefulness and corresponding chlorpromazine equivalent levels. Clinical demographic findings for true-positive, false-positive, true-negative, and false-negative groups are discussed. Overall findings suggest that this particular pattern of EMG marker activity observed in neuroleptic-treated patients during PSG and EMG studies is valuable in facilitating the diagnosis and monitoring treatment of NIA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:25:05