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Titolo:
A CLINICAL-TRIAL OF THE EFFECTS OF ESTROGEN IN ACUTELY PSYCHOTIC WOMEN
Autore:
KULKARNI J; DECASTELLA A; SMITH D; TAFFE J; KEKS N; COPOLOV D;
Indirizzi:
MONASH UNIV,DANDENONG HOSP,DEPT PSYCHOL MED DANDENONG VIC AUSTRALIA
Titolo Testata:
Schizophrenia research
fascicolo: 3, volume: 20, anno: 1996,
pagine: 247 - 252
SICI:
0920-9964(1996)20:3<247:ACOTEO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENDER DIFFERENCES; MENSTRUAL-CYCLE; SCHIZOPHRENIA; ESTRADIOL; AGE;
Keywords:
SCHIZOPHRENIA; GENDER; HORMONES; ESTROGEN; MENSTRUAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J. Kulkarni et al., "A CLINICAL-TRIAL OF THE EFFECTS OF ESTROGEN IN ACUTELY PSYCHOTIC WOMEN", Schizophrenia research, 20(3), 1996, pp. 247-252

Abstract

This study was a preliminary open clinical trial aimed at exploring the hypothesis that estrogen may provide protection against schizophrenia in women. Eleven women with acute psychotic symptoms, as scored on the BPRS, SAPS and SANS, had 0.02 mg estradiol added to neuroleptic treatment for eight weeks. Their response was compared to seven women with similar symptom severity receiving neuroleptic treatment alone. Both groups had baseline hormonal assays of estrogen, progesterone, LH and FSH and underwent regular psychopathology ratings during the eight weeks. The group receiving the estradiol adjunct showed more rapid improvement in psychotic symptoms compared with the group receiving neuroleptics only. This difference was not sustained for the entirety of thetrial. Both groups reached similar levels of recovery by the eighth week. These results suggest that estradiol may have antipsychotic properties and/or act as a catalyst for neuroleptic responsiveness in womenwith schizophrenia.

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Documento generato il 02/12/20 alle ore 07:05:52