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Titolo:
DP-2, A HETERODIMERIC PARTNER OF E2F - IDENTIFICATION AND CHARACTERIZATION OF DP-2 PROTEINS EXPRESSED IN-VIVO
Autore:
ROGERS KT; HIGGINS PDR; MILLA MM; PHILLIPS RS; HOROWITZ JM;
Indirizzi:
DUKE UNIV,MED CTR,DEPT MOLEC CANC BIOL,BOX 3686 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT MOLEC CANC BIOL DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT MICROBIOL DURHAM NC 27710
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 15, volume: 93, anno: 1996,
pagine: 7594 - 7599
SICI:
0027-8424(1996)93:15<7594:DAHPOE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR E2F; CELL-CYCLE; RETINOBLASTOMA PROTEIN; GENE-PRODUCT; COMPLEX-FORMATION; FACTOR DRTF1/E2F; BINDING PROTEIN; RB PROTEIN; TRANSACTIVATION; P107;
Keywords:
TRANSCRIPTION; RETINOBLASTOMA; CELL GROWTH REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
K.T. Rogers et al., "DP-2, A HETERODIMERIC PARTNER OF E2F - IDENTIFICATION AND CHARACTERIZATION OF DP-2 PROTEINS EXPRESSED IN-VIVO", Proceedings of the National Academy of Sciences of the United Statesof America, 93(15), 1996, pp. 7594-7599

Abstract

E2F is a heterodimeric transcription factor that regulates the expression of genes at the G1/S boundary and is composed of two related but distinct families of proteins, E2F and DP. E2F/DP heterodimers form complexes with the retinoblastoma (Rb) protein, the Rb-related proteins p107 and p130, and cyclins/cdks in a cell cycle-dependent fashion in vivo, E2F is encoded by at least five closely related genes, E2F-1 through -5. Here we report studies of DP-2, the second member of the DP family of genes. Our results indicate that (i) DP-2 encodes at least five distinct mRNAs, (ii) a site of alternative splicing occurs within the 5' untranslated region of DP-2 mRNA, (iii) at least three DP-2-related proteins (of 55, 48, and 43 kDa) are expressed in vivo, (iv) each of these proteins is phosphorylated, and (v) one DP-2 protein (43 kDa) carries a truncated amino terminus. Our data also strongly suggest that the 55-kDa DP-2-related protein is a novel DP-2 isoform that resultsfrom alternative splicing. Thus, we conclude that DP-2 encodes a set of structurally, and perhaps functionally, distinct proteins in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:14:59