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Titolo:
RNA-BINDING BY THE WILMS-TUMOR SUPPRESSOR ZINC-FINGER PROTEINS
Autore:
CARICASOLE A; DUARTE A; LARSSON SH; HASTIE ND; LITTLE M; HOLMES G; TODOROV I; WARD A;
Indirizzi:
UNIV OXFORD,DEPT ZOOL,CANC RES CAMPAIGN GROWTH FACTORS,S PARKS RD OXFORD OX1 3PS ENGLAND UNIV OXFORD,DEPT ZOOL,CANC RES CAMPAIGN GROWTH FACTORS OXFORD OX1 3PSENGLAND WESTERN GEN HOSP,MRC,HUMAN GENET UNIT EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND UNIV QUEENSLAND,CTR MOLEC & CELLULAR BIOL BRISBANE QLD 4072 AUSTRALIA
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 15, volume: 93, anno: 1996,
pagine: 7562 - 7566
SICI:
0027-8424(1996)93:15<7562:RBTWSZ>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH FACTOR-II; FACTOR-A-CHAIN; GENE-PRODUCT; TRANSCRIPTIONAL REPRESSION; WT1 GENE; LOCUS; MODULATION; PROMOTERS; SEQUENCE; DOMAINS;
Keywords:
EARLY GROWTH RESPONSE FACTOR 1; GENE EXPRESSION; INSULIN-LIKE GROWTH FACTOR II; POSTTRANSCRIPTIONAL REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A. Caricasole et al., "RNA-BINDING BY THE WILMS-TUMOR SUPPRESSOR ZINC-FINGER PROTEINS", Proceedings of the National Academy of Sciences of the United Statesof America, 93(15), 1996, pp. 7562-7566

Abstract

The Wilms tumor suppressor gene WT1 is implicated in the ontogeny of genito-urinary abnormalities, including Denys-Drash syndrome and Wilmstumor of the kidney. WT1 encodes Kruppel-type zinc finger proteins that can regulate the expression of several growth-related genes, apparently by binding to specific DNA sites located within 5' untranslated leader regions as well as 5' promoter sequences. Both WT1 and a closelyrelated early growth response factor, EGR1, can bind the same DNA sequences from the mouse gene encoding insulin-like growth factor 2 (Igf-2). We report that WT1, but not EGR1, can bind specific Igf-2 exonic RNA sequences, and that the zinc fingers are required for this interaction. WT1 zinc finger 1, which is not represented in EGR1, plays a moresignificant role in RNA binding than zinc finger 4, which does have acounterpart in EGR1. Furthermore, the normal subnuclear localization of WT1 proteins is shown to be RNase, but not DNase, sensitive. Therefore, WT1 might, like the Kruppel-type zinc finger protein TFIIIA, regulate gene expression by both transcriptional and posttranscriptional mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:50:36