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Titolo:
A MODEL FOR ACUTE CARBON-MONOXIDE POISONING IN CONSCIOUS RATS
Autore:
JIANG J; TYSSEBOTN I;
Indirizzi:
UNIV BERGEN,DEPT PHYSIOL,LAB HYPERBAR MED RES N-5009 BERGEN NORWAY
Titolo Testata:
Undersea & hyperbaric medicine
fascicolo: 2, volume: 23, anno: 1996,
pagine: 99 - 106
SICI:
1066-2936(1996)23:2<99:AMFACP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPOSURE; SEQUELAE; OXYGEN;
Keywords:
CARBON MONOXIDE POISONING; CEREBRAL ISCHEMIA; BRAIN EDEMA; NEUROLOGIC MANIFESTATIONS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J. Jiang e I. Tyssebotn, "A MODEL FOR ACUTE CARBON-MONOXIDE POISONING IN CONSCIOUS RATS", Undersea & hyperbaric medicine, 23(2), 1996, pp. 99-106

Abstract

These experiments were designed to establish an animal model of acutecarbon monoxide (GO) poisoning in awake habituated rats. On the day before exposure, under a brief anesthesia, a Levine preparation (unilateral common carotid artery occlusion) was performed on group 1 (n=8) and 2 (n=28), but not on group 3 rats (n=8). Group 1 rats were exposed to air as control. Groups 2 and 3 rats were exposed to 0.27% CO in airfor 60 min [carboxyhemoglobin (HbCO) = 70%] followed by a 2-day recovery in air. The Levine preparation per se did not induce any detectable physiologic effects on group 1 rats. Identical cardiovascular and metabolic responses to CO occurred in groups 2 and 3. After the CO exposure, all group 3 rats lived for 2 days with normal neurologic index (NI). In group 2 (n = 25 post-CO), 84% of the rats showed increased NI and edema of the ipsilateral cerebral hemisphere, and 76% of the rats died 8.7 +/- 1.7 h after the CO exposure. NI correlated with the brain edema (r(s) =0.748,P < 0.001) and inversely correlated with the survival time after the CO exposure (r(s) = -0.777, P < 0.001). We thereforemay conclude that exposure of the Levine-prepared rats to 0.27% CO inair for 60 min will provide a valuable model for testing of differenttreatments for CO poisoning.

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Documento generato il 04/04/20 alle ore 01:34:24