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Titolo:
THE PHARMACOLOGY OF THE EMETIC RESPONSE TO UPPER GASTROINTESTINAL-TRACT STIMULATION IN SUNCUS-MURINUS
Autore:
ANDREWS P; TORII Y; SAITO H; MATSUKI N;
Indirizzi:
ST GEORGE HOSP,SCH MED,DEPT PHYSIOL,CRANMER TERRACE LONDON SW17 0RE ENGLAND UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL TOKYO 113 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 307, anno: 1996,
pagine: 305 - 313
SICI:
0014-2999(1996)307:3<305:TPOTER>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CISPLATIN-INDUCED EMESIS; VAGAL AFFERENT TERMINALS; MOTION SICKNESS; ANTIEMETIC PROPERTIES; ANESTHETIZED FERRET; RECEPTOR ANTAGONIST; EXPERIMENTAL-MODEL; 5-HT3 RECEPTORS; 5-HYDROXYTRYPTAMINE; CP-99,994;
Keywords:
EMESIS; MORPHINE; NICOTINE; TACHYKININ NK1 RECEPTOR; 5-HT3 RECEPTOR; 5-HT1A RECEPTOR; RESINIFERATOXIN; VOMITING; RETCHING; (SUNCUS MURINUS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
P. Andrews et al., "THE PHARMACOLOGY OF THE EMETIC RESPONSE TO UPPER GASTROINTESTINAL-TRACT STIMULATION IN SUNCUS-MURINUS", European journal of pharmacology, 307(3), 1996, pp. 305-313

Abstract

This paper is the first to describe aspects of the mechanics of retching in the insectivore Suncus murinus (house musk shrew) and in an animal of such a small size (similar to 50 g), In anaesthetised animals using the novel stimulus of mechanical stimulation of the upper gastrointestinal tract as the provocative stimulus the frequency of retching was found to be about 4 retches/s, a much higher frequency than in other species (dog, cat, ferret). These studies show that quantification of retching in Suncus cannot be undertaken using direct observation. The temporal pattern of the emetic response was characterised in conscious Suncus using motion (1 Hz, 5 min) and nicotine (20 mg/kg s.c.). The ultrapotent capsaicin analogue resiniferatoxin (100 mu g/kg s.c.) was discovered to be highly emetic and comparative studies showed that nicotine and resiniferatoxin induced the most intense responses with episodes (retches and a vomit) occurring every 10-15 s. The retching response to mechanical stimulation in the anaesthetised Suncus was not blocked by a 5-HT3 receptor antagonist (granisetron, 1-5 mg/kg s.c.), a tachykinin NK1 receptor antagonist (CP-99,994 20 mg/kg s.c. dihydrochloride salt S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine) or morphine (2 mg/kg s.c.) but was blocked by the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT 100 mu g/kg s.c.). Suncus appears to be a suitable animal in which to study the pharmacology of the emetic response to mechanical stimulation of the gut. The results are discussed in the light of studies of the pharmacology of emesis in other species.

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Documento generato il 01/10/20 alle ore 01:18:30