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Titolo:
DIFFERENTIAL REGULATION OF LUTEINIZING-HORMONE RELEASE BY GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBTYPES IN THE ARCUATE-VENTROMEDIAL REGION OF THE CASTRATED RAM
Autore:
FERREIRA SA; SCOTT CJ; KUEHL DE; JACKSON GL;
Indirizzi:
UNIV ILLINOIS,DEPT VET BIOSCI,2001 S LINCOLN AVE URBANA IL 61801 UNIV ILLINOIS,DEPT VET BIOSCI URBANA IL 61801
Titolo Testata:
Endocrinology
fascicolo: 8, volume: 137, anno: 1996,
pagine: 3453 - 3460
SICI:
0013-7227(1996)137:8<3453:DROLRB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTERIOR HYPOTHALAMIC AREA; MEDIAL PREOPTIC AREA; BRAIN GABA LEVELS; OVARIECTOMIZED RATS; GABAERGIC NEURONS; PULSE-GENERATOR; ESTROUS-CYCLE; LH-SECRETION; SURGE; EWE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Ferreira et al., "DIFFERENTIAL REGULATION OF LUTEINIZING-HORMONE RELEASE BY GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBTYPES IN THE ARCUATE-VENTROMEDIAL REGION OF THE CASTRATED RAM", Endocrinology, 137(8), 1996, pp. 3453-3460

Abstract

We investigated the effects on LH secretion of infusing gamma-aminobutyric acid (GABA) agonists muscimol and baclofen (GABA(A) and GABA(B) receptor agonists, respectively) into either the medlar preoptic area (mPOA) or the arcuate-ventromedial region (ARC-VMR) of the hypothalamus of castrated rams during the nonbreeding season. Bilateral microdialysis of artificial cerebrospinal fluid for 4 h followed by treatment with artificial cerebrospinal fluid, baclofen (1 mM), or muscimol (1 mMin the ARC-VMR, 250 mu M in the mPOA) for 4 h was carried out on three separate occasions in random order. Simultaneously, jugular venous blood was collected at 10-min intervals, and plasma later was assayed for LH. The estimated dose of baclofen delivered to each unilateral microdialysis site was 7.9 mu g; for muscimol, it was 1.1 mu g for the mPOA and 4.5 mu g for the ARC-VMR. In the mPOA, baclofen had no detectable effect, whereas muscimol had a delayed suppressive effect on mean LH (P < 0.01). In the ARC-VMR muscimol rapidly reduced mean LH (P < 0.01). In contrast, baclofen increased mean LH (P = 0.01) and LH pulse amplitude (P = 0.05) without altering the LH interpulse interval (P > 0.10). These results support the involvement of GABA(A) receptors in themPOA in regulating LH secretory patterns. More importantly, both GABA(A) and GABA(B) receptors in the ARC-VMR appear to differentially modulate LH and, presumably, GnRH release. Whether GABA acts directly on the GnRH neuron or indirectly through other neural systems remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:57:16