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Titolo:
GENE HOMOLOGY BETWEEN ORF VIRUS AND SMALLPOX VARIOLA VIRUS
Autore:
MERCER AA; FRASER KM; ESPOSITO JJ;
Indirizzi:
UNIV OTAGO,HLTH RES COUNCIL,VIRUS RES UNIT,POB 56 DUNEDIN NEW ZEALAND UNIV OTAGO,CTR GENE RES DUNEDIN NEW ZEALAND CTR DIS CONTROL & PREVENT,POXVIRUS SECT,VIRAL EXANTHEMS & HERPESVIRUSES BRANCH ATLANTA GA 30333
Titolo Testata:
Virus genes
fascicolo: 2, volume: 13, anno: 1996,
pagine: 175 - 178
SICI:
0920-8569(1996)13:2<175:GHBOVA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SWINE FEVER VIRUS; VACCINIA VIRUS; SEQUENCE; GENOME; DNA; REVEALS; INVIVO;
Keywords:
ORF VIRUS; VARIOLA VIRUS; SMALLPOX; PARAPOXVIRUS; ORTHOPOXVIRUS; VACCINIA VIRUS; ECTROMELIA VIRUS; COWPOXVIRUS; AFRICAN SWINE FEVER VIRUS; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Mercer et al., "GENE HOMOLOGY BETWEEN ORF VIRUS AND SMALLPOX VARIOLA VIRUS", Virus genes, 13(2), 1996, pp. 175-178

Abstract

About 47% identity was observed between the deduced amino acid sequences of a protein encoded by a gene of the parapoxvirus orf virus (OV) strain NZ2 and a 6 kDa protein of unknown function reported to be produced by an open reading frame expressed early after infection by the orthopoxvirus Western Reserve vaccinia virus (VAC); the open reading frame is absent from VAC strain Copenhagen. Examination of sequences reported for variola virus (VAR) strains Bangladesh, India, Congo- 1970, Somalia- 1977 and Garcia- 1966 revealed each encoded a correlate 58 amino acid protein. The open reading frame was not reported in the original analyses of these sequences because a lower limit of 60 amino acids was used to identify potential encoded proteins. Inspection of partial reading frames reported for cowpox virus (CWV) and ectromelia virus(EMV) suggested that these viruses might also code for a correlate ofthe VAC WR protein, DNA sequencing of cloned fragments of CWV and EMVconfirmed that both these orthopoxviruses encode closely related, full length variants of the VAC and VAR open reading frames. The OV homologue is coded in the OV strain NZ2 BamHI-E fragment E2L open reading frame, which we reported is transcribed early postinfection; moreover, analysis of an NZ2 variant showed E2L was absent, indicating that E2L,like the VAC cognate, is nonessential for virus replication in cell culture. The parapoxvirus and orthopoxvirus correlates have about 20% amino acid sequence resemblance to African swine fever virus DNA binding protein p10, suggesting an ancestral relation of genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:12:25