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Titolo:
EFFECTS OF SURFACTANT THERAPY IN PREMATUR E-INFANTS WITH SEVERE RESPIRATORY-DISTRESS SYNDROME
Autore:
MORON A; LUACES J; ESTEBAN JC; MEDINA D; SANCHEZ JM; MANZANO JL;
Indirizzi:
HOSP MATERNO INFANTIL,UNIDAD CUIDADOS INTENS PEDIAT,AVE MARITIMA SUR S-N LAS PALMAS 35016 SPAIN
Titolo Testata:
Medicina Clinica
fascicolo: 5, volume: 107, anno: 1996,
pagine: 165 - 168
SICI:
0025-7753(1996)107:5<165:EOSTIP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
SPA
Soggetto:
PLACEBO-CONTROLLED TRIAL; BIRTH-WEIGHT INFANTS; RANDOMIZED CONTROLLED TRIAL; HYALINE-MEMBRANE DISEASE; 30 WEEKS GESTATION; REPLACEMENT THERAPY; SYNTHETIC SURFACTANT; BOVINE SURFACTANT; EXOGENOUS SURFACTANT; PULMONARY HEMORRHAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
A. Moron et al., "EFFECTS OF SURFACTANT THERAPY IN PREMATUR E-INFANTS WITH SEVERE RESPIRATORY-DISTRESS SYNDROME", Medicina Clinica, 107(5), 1996, pp. 165-168

Abstract

BACKGROUND: From January 1992 to June 1993 a study was performed to show whether the administration of surfactant to low birth weight infants with respiratory distress decreased the need for ventilatory support and improved survival. METHOD: Twenty three infants born at a singlehospital received the surfactant (one dose of a 100 mg/kg divided in four aliquots) and they were eligible for the treatment if they met the following criteria: 1) Weight between 650 g and 2000 g; 2) postnatalage 4 to 24 hours; 3) clinical-radiographic signs of respiratory distress, and 4) need of mechanical ventilation with FiO(2) greater than or equal to 0.6. The results of the treatment were evaluated comparing the arterial-alveolar oxygenation ratio, maximal inspiratory pressure and the oxygenation index before and after the administration of surfactant, The last consecutive eighteen infants born at our hospital, before our study was started, that met the same criteria were elected as control group. RESULTS: In the group of infants treated with surfactant the arterial-alveolar oxygenation ratio increased from 0.10 +/- 0.009 before treatment to 0.28 +/- 0.02 six hours after treatment (p < 0.01); the oxygenation index decreased from 37.79 +/- 4.27 to 12.71 +/- 1.17 (p < 0.01) and the maximal inspiratory pressure from 22.13 +/- 0.81 cmH(2)O to 19.52 +/- 0.76 (p < 0.001) in the same period of time, This improvement was maintained during the following 72 hours. In the group of infants treated with surfactant, mortality decreased (p < 0.01), the frequency of neumothorax diminished (p < 0.001) and the frequency of pulmonary haemorrhage increased (p < 0.05). The ventilatory time was similar in both groups of infants but the global length of stay ofthe newborn that received surfactant was longer due to the fact that the non survivors of the control group died before the 72 hours of life, CONCLUSIONS: Treatment with surfactant improves the initial evolution of the respiratory distress syndrome of the newborn and decreases mortality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:33:37