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Titolo:
PREDICTION OF TUMOR HYPOXIA AND RADIORESISTANCE WITH NUCLEAR-MEDICINEMARKERS
Autore:
CHAPMAN JD; COIA LR; STOBBE CC; ENGELHARDT EL; FENNING MC; SCHNEIDER RF;
Indirizzi:
FOX CHASE CANC CTR,DEPT RADIAT ONCOL,7701 BURHOLME AVE PHILADELPHIA PA 19111
Titolo Testata:
British Journal of Cancer
, volume: 74, anno: 1996, supplemento:, 27
pagine: 204 - 208
SICI:
0007-0920(1996)74:<204:POTHAR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
IODOAZOMYCIN ARABINOSIDE; CANCER; OXYGEN; MISONIDAZOLE; THERAPY; CELLS; PO2;
Keywords:
IODOAZOMYCIN ARABINOSIDE; BETA-D-IODOAZOMYCIN GALACTOSIDE; BETA-D-IODOAZOMYCIN XYLOPYRANOSIDE; SINGLE PHOTON EMISSION COMPUTERIZED TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Chapman et al., "PREDICTION OF TUMOR HYPOXIA AND RADIORESISTANCE WITH NUCLEAR-MEDICINEMARKERS", British Journal of Cancer, 74, 1996, pp. 204-208

Abstract

Second-generation nuclear medicine markers of tumour hypoxia have been synthesised and screened for hypoxic marking activity in cell cultures and in mouse tumours (EMT-6). Markers of the iodinated azomycin nucleoside class with greater water solubility and faster plasma clearance rates relative to iodoazomycin arabinoside (IAZA) were of particularinterest. The test systems used to characterise hypoxic marking activity of compounds included (1) covalent linkage of radiolabelled markers to cells in suspension culture equilibrated with specific O-2 concentrations; (2) biodistribution of radiolabelled markers in EMT-6 tumour-bearing mice; and (3) biodistribution in R3327-AT tumour-bearing ratsby nuclear medicine procedures. Of the iodinated azomycin nucleosidesproduced to date, beta-D-iodoazomycin galactoside (beta-D-IAZG) and beta-D-iodoazomycin xylopyranoside (beta-D-IAZXP) exhibited high metabolism-dependent hypoxic cell uptake, rapid clearance kinetics from the blood and excellent tumour marking activity in vivo. Tumour-blood (T/B) ratio (a measure of tumour hypoxic fraction) was dependent upon EMT-6 tumour size and implantation site. The radioresistance of individualtumours was measured by in vivo/in vitro assay and correlated well with the T/B ratio of hypoxic marker. These studies have identified beta-D-IAZG and beta-D-IAZXP as effective hypoxic markers for planar and single photon emission computerised tomography (SPECT) imaging studies of tumour oxygenation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 00:43:47