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Titolo:
COMPARTMENTAL LOCALIZATION OF A METABOTROPIC GLUTAMATE-RECEPTOR (MGLUR7) - 2 DIFFERENT ACTIVE-SITES AT A RETINAL SYNAPSE
Autore:
BRANDSTATTER JH; KOULEN P; KUHN R; VANDERPUTTEN H; WASSLE H;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,ABT NEUROANAT,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY CIBA GEIGY AG,CENT NERVOUS SYST RES CH-4002 BASEL SWITZERLAND
Titolo Testata:
The Journal of neuroscience
fascicolo: 15, volume: 16, anno: 1996,
pagine: 4749 - 4756
SICI:
0270-6474(1996)16:15<4749:CLOAMG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ROD BIPOLAR CELLS; MAMMALIAN RETINA; GLYCINE-RECEPTOR; RAT RETINA; MOLECULAR CHARACTERIZATION; SIGNAL-TRANSDUCTION; MESSENGER-RNAS; EXPRESSION; IMMUNOREACTIVITY;
Keywords:
CONE BIPOLAR CELLS; RIBBON SYNAPSE; MGLUR7; AUTORECEPTOR; PRESYNAPTIC; POSTSYNAPTIC; RAT RETINA; RETINAL DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Brandstatter et al., "COMPARTMENTAL LOCALIZATION OF A METABOTROPIC GLUTAMATE-RECEPTOR (MGLUR7) - 2 DIFFERENT ACTIVE-SITES AT A RETINAL SYNAPSE", The Journal of neuroscience, 16(15), 1996, pp. 4749-4756

Abstract

The distribution of the metabotropic glutamate receptor 7 (mGluR7) was studied in the rat retina using a specific antiserum. Punctate immunofluorescence that corresponded to synaptic localization was present exclusively in the inner plexiform layer. Double-labeling experiments suggested that mGluR7 is expressed at the synaptic terminals of certaincone bipolar cells. Electron microscopy showed that mGluR7 was present both presynaptically, as an autoreceptor in cone bipolar cell ribbonsynapses, and postsynaptically in amacrine cells. There are usually two postsynaptic processes at a bipolar cell ribbon synapse; however, the presynaptic aggregation of mGluR7 was restricted to one half of theactive zone and therefore was opposed to only one of the postsynapticprocesses. This selective localization of mGluR7 could differentiallyregulate the glutamate release from the ribbon synapse, thus leading to a differential activation of the postsynaptic neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:49:15